N. Safdar

Publications538
h-index65
Citations17,655
Highly Influential Citations625
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Clinical and economic consequences of ventilator-associated pneumonia: A systematic review
TLDR
Ventilator-associated pneumonia occurs in a considerable proportion of patients undergoing mechanical ventilation and is associated with substantial morbidity, a two-fold mortality rate, and excess cost, and strategies that effectively prevent VAP are urgently needed.
The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention.
TLDR
Routine surveillance of VAPs is mandatory, and high-risk patients, especially those with prolonged granulocytopenia or organ transplants, should be cared for in hospital units with high-efficiency-particulate-arrestor filtered air.
Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis.
TLDR
The galactomannan assay has moderate accuracy for diagnosis of invasive aspergillosis in immunocompromised patients and is more useful in patients who have hematological malignancy or who have undergone hematopoietic cell transplantation than in solid-organ transplant recipients.
Meta-Analysis: Methods for Diagnosing Intravascular DeviceRelated Bloodstream Infection
TLDR
A meta-analysis summarized data from 51 studies for 8 diagnostic methods to determine the most accurate diagnostic methods for IVD-related bloodstream infection and found several methods had reasonable accuracy.
The risk of infection after nasal colonization with Staphylococcus aureus.
Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials.
TLDR
Two treatment-related factors were associated with improved survival and greater clinical success: use of an echinocandin and removal of the CVC.
Voriconazole Therapeutic Drug Monitoring
TLDR
A relationship (P < 0.025) between disease progression and drug concentration was detected and favorable responses were observed in 10/10 patients with concentrations above 2.05 μg/ml, while disease progressed in 44% (n = 18).
Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysis.
TLDR
A meta-analysis of 26 studies published from January 1983 to February 2001 found that there does not appear to be an increased risk of HUS with antibiotic treatment of E coli O157:H7 enteritis, indicating that a randomized trial of adequate power is needed to conclusively determine whether antibiotic treatment.
The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC): Results From a Multispecialty Panel Using the RAND/UCLA Appropriateness Method
TLDR
A multidisciplinary meeting of national and international experts was organized and conducted to develop appropriateness criteria for use, care, and management of PICCs and related VADs in hospitalized patients.
Current Trends in the Epidemiology and Outcomes of Clostridium difficile Infection.
  • C. Evans, N. Safdar
  • Medicine, Biology
    Clinical infectious diseases : an official…
  • 15 May 2015
TLDR
The impact of antibiotics as a risk factor for new-onset CDI is well established; however, recognizing classes of antibiotics with the highest risks and reducing unnecessary antibiotic use are important strategies for prevention of CDI and subsequent recurrence.
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