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Identification of a Novel Human ADP Receptor Coupled to Gi *
We have cloned and expressed a novel human G-protein-coupled receptor closely related to the human P2Y12 receptor. It corresponds to the orphan receptor called GPR86. GPR86 proved to be a Gi-coupledExpand
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Pharmacological characterization of the human P2Y13 receptor.
The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi andExpand
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Overview of the P2 receptors.
The release of nucleotides in extracellular fluids can result from cell necrosis, exocytosis of secretory granules (such as platelet dense granules), or efflux through membrane channels. In addition,Expand
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Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells.
Extracellular adenosine triphosphate affects the maturation of human monocyte-derived dendritic cells (DCs), mainly by inhibiting T-helper 1 (Th1) cytokines, promoting Th2 cytokines, and modulatingExpand
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Extracellular Adenine Nucleotides Inhibit the Activation of Human CD4+ T Lymphocytes1
ATP has been reported to inhibit or stimulate lymphoid cell proliferation, depending on the origin of the cells. Agents that increase cAMP, such as PGE2, inhibit human CD4+ T cell activation. WeExpand
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The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids
Several orphan G protein-coupled receptors are structurally close to the family of P2Y nucleotide receptors: GPR80/99 and GPR91 are close to P2Y1/2/4/6/11 receptors, whereas GPR87, H963 and GPR34 areExpand
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15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism.
Retinal pigment epithelial (RPE) cells constitute the external part of the blood-retinal-barrier and play a pivotal role in the regulation of retinal immunity. In the present work, we investigatedExpand
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HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase‐dependent way
We were looking by a proteomic approach for new phospho‐proteins involved during the early steps of the TNF + cycloheximide (CHX)‐induced apoptosis—preceding mitochondrial membraneExpand
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