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A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer.
UNLABELLED Only a fraction of patients with metastatic colorectal cancer receive clinical benefit from therapy with anti-epidermal growth factor receptor (EGFR) antibodies, which calls for theExpand
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The Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer
Colorectal cancer is the third most common cancer worldwide, with 1.2 million patients diagnosed annually. In late-stage colorectal cancer, the most commonly used targeted therapies are theExpand
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Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results
BackgroundLiver surgery, especially for cirrhotic patients, is one of the last areas of resistance to progress in laparoscopic surgery. This study compares the postoperative results and the 2-yearExpand
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Evolution of Long-Term Outcome of Liver Resection for Colorectal Metastases: Analysis of Actual 5-Year Survival Rates over Two Decades
BackgroundLiver resection (LR) is the only potentially curative treatment of colorectal liver metastases (CRLM). Its outcome over the past 2 decades was studied using actual 5-year survivalExpand
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Comparison of laparoscopic and open intraoperative ultrasonography for staging liver tumours
Laparoscopic liver surgery must reproduce open surgical steps. Intraoperative ultrasonography (IOUS) is mandatory, but reliability of laparoscopic IOUS has been poorly evaluated. The aim of thisExpand
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Does Pringle Maneuver Affect Survival in Patients with Colorectal Liver Metastases?
BackgroundThe purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases.MethodsEighty patients with colorectalExpand
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Laparoscopic left lateral hepatic lobectomy: a safer and faster technique.
BACKGROUND/PURPOSE Laparoscopy for liver resection is highly specialized field because laparoscopic liver surgery presents severe technical difficulties, such as control of bleeding and risk of gasExpand
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Laparoscopic liver resections for hepatocellular carcinoma (HCC) in cirrhotic patients.
BACKGROUND The laparoscopic approach for liver resections is still limited and controversial. Nevertheless the advantages connected with a mini-invasive approach are significant, especially inExpand
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The role of liver-directed surgery in patients with hepatic metastasis from primary breast cancer: a multi-institutional analysis.
BACKGROUND Data on surgical management of breast liver metastasis are limited. We sought to determine the safety and long-term outcome of patients undergoing hepatic resection of breast cancer liverExpand
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Liver resection with thrombectomy as a treatment of hepatocellular carcinoma with major vascular invasion: results from a retrospective multicentric study.
BACKGROUND The role of liver resection (LR) of hepatocellular carcinoma with macroscopic vascular thrombosis (MVT) remains controversial. The aim of this study is to evaluate whether the presence ofExpand
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