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Neurotoxicity assessment using zebrafish.
TLDR
The results support the use of zebrafish as a predictive model for assessing neurotoxicity and effects of drug treatment on different neurons can easily be visually assessed and quantified in intact animals. Expand
Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.
Zebrafish embryos are emerging as models of glucose metabolism. However, patterns of endogenous glucose levels, and the role of the islet in glucoregulation, are unknown. We measured absolute glucoseExpand
An early Fgf signal required for gene expression in the zebrafish hindbrain primordium.
TLDR
An early role for Fgf signaling is demonstrated and a dynamic relationship between the RA and FgF signaling pathways during hindbrain development is revealed, indicating that these signaling pathways become redundant at later stages. Expand
A zebrafish assay for identifying neuroprotectants in vivo.
TLDR
Results in zebrafish were similar to results reported in mammals supporting the utility of this in vivo method for identifying potential neuroprotective anti-oxidants, including L-hydroxyglutaric acid and alpha-tocopherol. Expand
Glyphosate induces neurotoxicity in zebrafish.
TLDR
It is concluded that glyphosate and the Roundup(®) formulation is developmentally toxic to the forebrain and midbrain but does not affect the hindbrain after 24 h exposure. Expand
Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes.
TLDR
Data show that a short embryonic exposure to a neurotoxicant can alter development of neural synapses and lead to changes in adult behavior. Expand
Glyphosate induces cardiovascular toxicity in Danio rerio.
TLDR
Glyphosate is developmentally toxic to the zebrafish heart and alterations in the Mef2/mef2ca staining patterns during early cardiac patterning stages are found. Expand
Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4
TLDR
It is demonstrated that expression in the rostral hindbrain requires acerebellar (ace/fgf8) and spiel ohne grenzen (spg/pou2) activity and the expression of zebrafish lmo4 during the first 48 h of development is reported. Expand
Evaluation of the developmental toxicity of lead in the Danio rerio body.
TLDR
It is concluded that lead is developmentally toxic to other areas of the developing embryo, not just the brain, as well as motor neuron alterations. Expand
Di-butyl phthalate (DBP) induces craniofacial defects during embryonic development in zebrafish
TLDR
Exposure to DBP during crucial time windows of embryonic development is toxic to craniofacial development, including a decrease in overall cranial size in DBP treated embryos, but the intraocular distance was increased compared to controls. Expand
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