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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand.
The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1.8 A resolution crystal structure of the complexExpand
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Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
The 2.0-Å crystal structure of the ligand-binding domain (LBD) of the human retinoic acid receptor (RAR)-γ bound to all-trans retinoic acid reveals the ligand-binding interactions and suggests anExpand
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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
The 2.0-A crystal structure of the ligand-binding domain (LBD) of the human retinoic acid receptor (RAR)-gamma bound to all-trans retinoic acid reveals the ligand-binding interactions and suggests anExpand
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BACTERIAL IRON TRANSPORT : COORDINATION PROPERTIES OF PYOVERDIN PAA, A PEPTIDIC SIDEROPHORE OF PSEUDOMONAS AERUGINOSA
Pyoverdin PaA is a siderophore excreted by Pseudomonas aeruginosa, a common and pathogenic bacterium. It belongs to a family of fluorescent iron(III) biological ligands. Its chemical structure showsExpand
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Crystal Structure of the Ligand-binding Domain of the Ultraspiracle Protein USP, the Ortholog of Retinoid X Receptors in Insects*
The major postembryonic developmental events happening in insect life, including molting and metamorphosis, are regulated and coordinated temporally by pulses of ecdysone. The biological activity ofExpand
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Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
The ecdysteroid hormones coordinate the major stages of insect development, notably moulting and metamorphosis, by binding to the ecdysone receptor (EcR); a ligand-inducible nuclear transcriptionExpand
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Crystal structure of the human RXRα ligand‐binding domain bound to its natural ligand: 9‐cis retinoic acid
The pleiotropic effects of active retinoids are transduced by their cognate nuclear receptors, retinoid X receptors (RXRs) and retinoic acid receptors (RARs), which act as transcriptional regulatorsExpand
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Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
Nuclear hormone receptors (NHRs) control numerous physiological processes through the regulation of gene expression. The present study provides a structural basis for understanding the role of DNA inExpand
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Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Here, we present the cryoExpand
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Retinoic Acid Receptors Recognize the Mouse Genome through Binding Elements with Diverse Spacing and Topology*
Background: Retinoic acid receptors (RARs) heterodimerize with retinoid X receptors (RXRs) to regulate gene expression. Results: This heterodimer recognizes the genome via a large and diverseExpand
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