• Publications
  • Influence
Small Interfering RNA Profiling Reveals Key Role of Clathrin-Mediated Endocytosis and Early Endosome Formation for Infection by Respiratory Syncytial Virus
TLDR
It is concluded that, while RSV may be competent to enter at the cell surface, clathrin function and endocytosis are a necessary and important part of a productive RSV infection, even though infection is strictly independent of pH. Expand
Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro.
TLDR
Normal volunteers were exposed sequentially to air or NO2, by double-blind randomization, in an environmental chamber to examine the effect of NO2 inhalation on human alveolar macrophages, which has the potential to identify pollutant effects on mechanisms of respiratory defense in humans. Expand
Human Lymphocyte Apoptosis after Exposure to Influenza A Virus
TLDR
The present studies showed that Fas-FasL signaling plays a major role in the induction of apoptosis in lymphocytes after exposure to IAV, which likely represents a part of an overall beneficial immune response but could be a possible mechanism of disease pathogenesis. Expand
Nitrogen dioxide exposure: effects on airway and blood cells.
TLDR
In healthy subjects, exposures to NO(2) at levels found indoors cause mild airway inflammation, effects on blood cells, and increased susceptibility of airway epithelial cells to injury from respiratory viruses. Expand
Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletion.
TLDR
Although the subjects had only partial responses to immune function testing, the rate of opportunistic infections was very low, and none of the tests was predictive of risk. Expand
Genetic evaluation of suspected cases of transient HIV-1 infection of infants.
TLDR
It is argued that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented. Expand
Suppressed expression of ICAM-1 and LFA-1 and abrogation of leukocyte collaboration after exposure of human mononuclear leukocytes to respiratory syncytial virus in vitro. Comparison with exposure to
TLDR
The possibility that exposure of MNL to RSV fails to elicit or blocks the early events necessary for cellular collaboration, contributing to early suppression of the clonal expansion of RSV-specific lymphocytes is raised. Expand
Use of FITC-labeled influenza virus and flow cytometry to assess binding and internalization of virus by monocytes-macrophages and lymphocytes
TLDR
This procedure provides a simple and effective method to distinguish surface-bound from internalized influenza virus, and allows precise kinetic analyses on large numbers of cells. Expand
Interleukin-6⁻¹⁷⁴ and tumor necrosis factor α⁻³⁰⁸ polymorphisms enhance cytokine production by human macrophages exposed to respiratory viruses.
TLDR
Results show that IL-6 and TNFα gene polymorphisms lead to enhanced production of the respective cytokines when exposed to specific respiratory viruses, which may influence the susceptibility to, severity of, and recovery from respiratory virus infections, or influence the immune response to and reactogenicity of viral vaccines. Expand
...
1
2
3
4
5
...