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A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
Hereditary haemochromatosis (HH), which affects some 1 in 400 and has an estimated carrier frequency of 1 in 10 individuals of Northern European descent, results in multi–organ dysfunction caused byExpand
The Future of Genetic Studies of Complex Human Diseases
TLDR
The identification of the genetic basis of complex human diseases such as schizophrenia and diabetes has proven difficult. Expand
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Objective. —To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. DataExpand
Linkage strategies for genetically complex traits. I. Multilocus models.
  • N. Risch
  • Biology, Medicine
  • American journal of human genetics
  • 1 February 1990
In order to investigate linkage detection strategies for genetically complex traits, multilocus models of inheritance need to be specified. Here, two types of multilocus model are described: (1) aExpand
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
OBJECTIVE To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. DATAExpand
Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide
The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but genetic studies have produced conflicting results and demonstratedExpand
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.
CONTEXT Substantial resources are being devoted to identify candidate genes for complex mental and behavioral disorders through inclusion of environmental exposures following the report of anExpand
Searching for genetic determinants in the new millennium
  • N. Risch
  • Biology, Medicine
  • Nature
  • 15 June 2000
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing moreExpand
Genetic heritability and shared environmental factors among twin pairs with autism.
CONTEXT Autism is considered the most heritable of neurodevelopmental disorders, mainly because of the large difference in concordance rates between monozygotic and dizygotic twins. OBJECTIVE ToExpand
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