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Analogues in other mammals and in fish of human plasma proteins, C-reactive protein and amyloid P component
TLDR
The isolation (using calcium-dependent affinity chromatography) of proteins closely resembling human SAP, from sera of other mammals, amphibia and fish, and of proteins from the plaice and the chicken are reported for the first time. Expand
Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein.
TLDR
To elucidate to homogeneity, obtained the NH2-terminal sequence from both the intact protein and derived tryptic and V8 protease peptides and isolated CALLA cDNAs from a Nalm-6 cell line lambda gt10 library using redundant oligonucleotide probes and predicted a 750-amino acid integral membrane protein that could function as both a transmembrane region and a signal peptide. Expand
Immunoglobulin flexibility in complement activation.
TLDR
In this discussion, Arnold Feinstein and his colleagues are concerned with the initial step in the classical pathway of complement activation, namely the activation of the first complement component after it has bound to a site on the Fc portion of an antibody molecule. Expand
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation
TLDR
Concentrations of soluble CD4 in the nanomolar range, like certain anti-CD4 monoclonal antibodies, inhibit syncytium formation and HIV infection by binding gp120-expressing cells, and class II specific T-cell interactions are uninhibited by solubleCD4 protein, whereas they are virtually abrogated by equivalent amounts of anti-T4 antibody. Expand
Functional and Molecular Aspects of Human T Lymphocyte Activation via T3‐Ti and Tl1 Pathways
TLDR
The ability of the T3-Ti complex to regulate T11-mediated activation is discussed with reference to its possible role in thymic selection. Expand
Isolation and partial characterization of sheep transferrin.
TLDR
The results provide evidence that sheep transferrin is a single polypeptide chain. Expand
Functional and molecular aspects of human T lymphocyte activation via T3-Ti and T11 pathways.
TLDR
The ability of the T3-Ti complex to regulate T11-mediated activation is discussed with reference to its possible role in thymic selection. Expand
Interchain disulphide bridges of mouse immunoglobulin M.
Mouse IgM (immunoglobulin M) was selectively and partially reduced and treated with iodo[2-14C]acetate to label the interchain disulphide bridges. The carboxymethylation was studied in some detail.Expand
Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor.
TLDR
The data suggest that the aglycosylated IgG2a has a structure which differs in the CH2 domain from the native IgG 2a, and that the heterogeneous N-linked oligosaccharides of this monoclonal IgG1a play a role in maintaining the integrity of its monocyte-binding site. Expand
Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.
The T11 (CD2) sheep-erythrocyte-binding protein is a T-cell surface molecule involved in activation of T lymphocytes and thymocytes, including those lacking the T3-Ti antigen-receptor complex. TheExpand
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