N. Ramasubbu

Publications114
h-index26
Citations3,375
Highly Influential Citations95
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Genes involved in the synthesis and degradation of matrix polysaccharide in Actinobacillus actinomycetemcomitans and Actinobacillus pleuropneumoniae biofilms.
Biofilms are composed of bacterial cells embedded in an extracellular polysaccharide matrix. A major component of the Escherichia coli biofilm matrix is PGA, a linear polymer of… Expand
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Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition
Bacterial infections are serious complications after orthopaedic implant surgery. Staphylococci, with Staphylococcus epidermidis as a leading species, are the prevalent and most important species… Expand
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Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae.
Most field isolates of the swine pathogen Actinobacillus pleuropneumoniae form tenacious biofilms on abiotic surfaces in vitro. We purified matrix polysaccharides from biofilms produced by A.… Expand
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Enzymatic Detachment of Staphylococcus epidermidis Biofilms
ABSTRACT The gram-positive bacterium Staphylococcus epidermidis is the most common cause of infections associated with catheters and other indwelling medical devices. S. epidermidis produces an… Expand
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Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.
Salivary alpha-amylase, a major component of human saliva, plays a role in the initial digestion of starch and may be involved in the colonization of bacteria involved in early dental plaque… Expand
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Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva.
The major components of human submandibular-sublingual saliva (HSMSL) are mucins, amylases, cystatins, proline-rich proteins and statherin. Structure-function studies of these molecules have been… Expand
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Detachment and Killing of Aggregatibacter actinomycetemcomitans Biofilms by Dispersin B and SDS
The periodontopathogen Aggregatibacter actinomycetemcomitans forms tenacious biofilms on abiotic surfaces in vitro. The objective of the present study was to measure the susceptibility of A.… Expand
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Candidacidal activity prompted by N-terminus histatin-like domain of human salivary mucin (MUC7)1.
Histidine-rich peptides (histatins, Hsn) in saliva are thought to provide a non-immune defense against Candida albicans. Sequence homology search of the human salivary mucin, MUC7, against histatins… Expand
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Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.
Mammalian amylases harbor a flexible, glycine-rich loop 304GHGAGGA(310), which becomes ordered upon oligosaccharide binding and moves in toward the substrate. In order to probe the role of this loop… Expand
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Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance in Aggregatibacter actinomycetemcomitans.
Clinical isolates of the periodontopathogen Aggregatibacter actinomycetemcomitans form matrix-encased biofilms on abiotic surfaces in vitro. A major component of the A. actinomycetemcomitans biofilm… Expand
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