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Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.
TLDR
The protective effect of O-Trensox against iron toxicity induced in hepatocyte cultures by ferric citrate was shown by decreased release of the enzymes lactate dehydrogenase, aspartate isinotransferase, and alanine aminotranferase from the cultures and, using electron paramagnetic resonance (EPR) measurements, decreased production of lipid radicals. Expand
Liver iron is a surrogate marker of severe fibrosis in chronic hepatitis C.
TLDR
Liver iron should be considered more as a surrogate marker for disease severity than as a fibrogenic factor per se, according to the results of this study. Expand
Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines.
TLDR
The results show that TRX, at concentrations of 20-50 microM, strongly inhibits cell proliferation and induces apoptosis in proliferating and non-proliferating HepG2 and HBG cells, respectively, and DFO is not a strong inducer of apoptosis. Expand
Bgugaine, a pyrrolidine alkaloid from Arisarum vulgare, is a strong hepatotoxin in rat and human liver cell cultures.
TLDR
The data suggest that the alkaloid bgugaine contained in Arisarum vulgarae may be involved in the toxicologic symptoms observed after consumption of this plant tubers by humans and animals. Expand
Irniine, a pyrrolidine alkaloid, isolated from Arisarum vulgare can induce apoptosis and/or necrosis in rat hepatocyte cultures.
TLDR
The data suggest that the alkaloid irniine contained in A. vulgare may be involved in the toxic symptoms observed after medicinal use or consumption of the plant tubers as food both by humans and animals. Expand
Iron mobilization, cytoprotection, and inhibition of cell proliferation in normal and transformed rat hepatocyte cultures by the hydroxypyridinone CP411, compared to CP20: a biological and
TLDR
CP411 is more efficient to protect the hepatocyte from the toxic effect of iron load and to inhibit tumor cell proliferation since equimolar solutions of the two chelators in an acellular system exhibit the same ability to inhibit the Fenton reaction. Expand
New 8-hydroxyquinoline and catecholate iron chelators: influence of their partition coefficient on their biological activity.
TLDR
CacCAM, the unique catecholate, was the most efficient of the molecules tested, as well as being the least toxic in the cellular model despite having the lowest value of pFe, suggesting the use of the partition coefficient and p Fe, as tools for predicting biological activity of iron chelators should be not generalized. Expand
Iron mobilization, cytoprotection, and inhibition of cell proliferation in normal and transformed rat hepatocyte cultures by the hydroxypyridinone CP411, compared to CP20: a biological and
TLDR
CP411 is more efficient to protect the hepatocyte from the toxic effect of iron load and to inhibit tumor cell proliferation since equimolar solutions of the two chelators in an acellular system exhibit the same ability to inhibit the Fenton reaction. Expand
Cytoprotection and iron mobilization in rat hepatocyte cultures by a new synthetic dihydroxamate chelator.
TLDR
KD is effective at a level comparable to DFO in protecting rat hepatocytes against the toxic effect of iron-citrate by decreasing the uptake of the metal and increasing its release from the cells. Expand