• Publications
  • Influence
Combinatorial microRNA target predictions
MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3′ untranslated regions of target genes in animals and, by unknown mechanisms, regulate proteinExpand
  • 4,361
  • 320
  • PDF
Circular RNAs are a large class of animal RNAs with regulatory potency
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA.Expand
  • 3,346
  • 284
  • PDF
Widespread changes in protein synthesis induced by microRNAs
Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAsExpand
  • 3,113
  • 153
  • PDF
circRNA biogenesis competes with pre-mRNA splicing.
Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their biogenesis and possible functions are poorly understood. Here, by studying circRNAs that we identified in neuronalExpand
  • 1,226
  • 113
Silencing of microRNAs in vivo with ‘antagomirs’
MicroRNAs (miRNAs) are an abundant class of non-coding RNAs that are believed to be important in many biological processes through regulation of gene expression. The precise molecular function ofExpand
  • 3,583
  • 105
  • PDF
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
microRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally regulate the expression of a large fraction of all animal genes and are important in a wide range ofExpand
  • 1,354
  • 98
  • PDF
Regulation of the Germinal Center Response by MicroRNA-155
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155)Expand
  • 1,405
  • 68
Discovering microRNAs from deep sequencing data using miRDeep
The capacity of highly parallel sequencing technologies to detect small RNAs at unprecedented depth suggests their value in systematically identifying microRNAs (miRNAs). However, the identificationExpand
  • 988
  • 67
  • PDF
A pancreatic islet-specific microRNA regulates insulin secretion
MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression. Several miRNAs in animals exhibit tissue-specific orExpand
  • 1,856
  • 63
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.
Circular RNAs (circRNAs) are an endogenous class of animal RNAs. Despite their abundance, their function and expression in the nervous system are unknown. Therefore, we sequenced RNA from differentExpand
  • 948
  • 57