• Publications
  • Influence
Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome
Methylglyoxal (MG) is a potent protein glycating agent. Glycation is directed to guanidino groups of arginine residues forming mainly hydroimidazoloneExpand
  • 248
  • 18
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. EnzymesExpand
  • 160
  • 14
  • PDF
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on exposure to high glucose concentrations, inflammation, cell aging and senescence. It is associated withExpand
  • 179
  • 10
  • PDF
Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.
Protection of mitochondrial proteins from glycation by endogenous dicarbonyl compounds, methylglyoxal and glyoxal, was found recently to prevent increased formation of reactive oxygen species andExpand
  • 131
  • 10
  • PDF
Activation of NF-E2–Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease
OBJECTIVE—Sulforaphane is an activator of transcription factor NF-E2–related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). Nrf2 regulates theExpand
  • 202
  • 7
C. elegans as Model for the Study of High Glucose– Mediated Life Span Reduction
OBJECTIVE Establishing Caenorhabditis elegans as a model for glucose toxicity–mediated life span reduction. RESEARCH DESIGN AND METHODS C. elegans were maintained to achieve glucose concentrationsExpand
  • 183
  • 7
Glyoxalase in tumourigenesis and multidrug resistance.
Since the discovery by Warburg of high aerobic glycolysis in most tumours in the 1920s, it has remained unclear how to exploit this in chemotherapy. The aim of this review is to assess the evidenceExpand
  • 120
  • 6
Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes
OBJECTIVE The goal of this study was to characterize glycation adducts formed in both in vivo extracellular matrix (ECM) proteins of endoneurium from streptozotocin (STZ)-induced diabetic rats and inExpand
  • 130
  • 6
  • PDF
Glyoxalase in diabetes, obesity and related disorders.
Diabetes was the first disease state where evidence emerged for increased formation of methylglyoxal. Metabolism of methylglyoxal by the glyoxalase system has been linked to the development ofExpand
  • 183
  • 5
Glycation research in amino acids: a place to call home
This is an introduction to a collection of review articles by leading investigators in the field of protein glycation research, see following articles in this issue. With this we launch a section ofExpand
  • 93
  • 5