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Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8.

• Y Zhao, Y. J. Guo, +5 authors Hagen Westphal
• Proceedings of the National Academy of Sciences…
• 1999

Formation of the mammalian secondary palate is a highly regulated and complex process whose impairment often results in cleft palate, a common birth defect in both humans and animals.… (More)

Software project development cost estimation

• Barbara A. Kitchenham, N. R. Taylor
• Journal of Systems and Software
• 1985

Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.

• N. R. Taylor, Mark von Itzstein
• Journal of medicinal chemistry
• 1994

A molecular modeling study has been used to investigate the structural and energetic aspects of substrate and inhibitor binding and the mechanism of catalysis of influenza virus sialidase. A detailed… (More)

Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo.

• N. R. Taylor, Berkan Kaplan, Piotr M Swiderski, Hongyun Li, John J. Rossi
• Nucleic acids research
• 1992

Subsequent to the discovery that RNA can have site specific cleavage activity, there has been a great deal of interest in the design and testing of trans-acting catalytic RNAs as both surrogate… (More)

Anionic phospholipids bind to L-selectin (but not E-selectin) at a site distinct from the carbohydrate-binding site.

• R. Malhotra, N. R. Taylor, M. I. Bird
• The Biochemical journal
• 1996

It is known that L-selectin binds to glycoconjugates containing the tetrasaccharide sialyl Lewis X in a Ca2+-dependent manner. In addition, a number of other acidic oligosaccharides (for example… (More)

Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus.

• A. K. Chong, Michael S. Pegg, N. R. Taylor, Mark von Itzstein
• European journal of biochemistry
• 1992

The enzyme mechanism of sialidase from influenza virus has been investigated by kinetic isotope methods, NMR, and a molecular dynamics simulation of the enzyme-substrate complex. Comparison of the… (More)

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of…

• N. R. Taylor, Anne Cleasby, +9 authors J. Varghese
• Journal of medicinal chemistry
• 1998

The first paper in this series (see previous article) described structure-activity studies of carboxamide analogues of zanamivir binding to influenza virus sialidase types A and B and showed that… (More)

The World Wide Web as a graphical user interface to program macros for molecular graphics, molecular modeling, and structure-based drug design.

• N. R. Taylor, R. Smith
• Journal of molecular graphics
• 1996

In this article we describe how the World Wide Web (WWW or Web) has been employed to provide access to computational chemistry software and protein structure data via program macros. We show how the… (More)

Differential laser absorption spectroscopy of uranium in an atmospheric pressure laser-induced plasma.

• N. R. Taylor, M. C. Phillips
• Optics letters
• 2014

A two-beam differential laser absorption technique is used to measure 238U absorption spectra with high signal-to-noise ratios in an atmospheric pressure laser-induced plasma. High-resolution… (More)

Studies in phaeochromocytoma. III. The excretion of noradrenaline in the urine of cases of hypertension and its value in the diagnosis of phaeochromocytoma.

• Gemma West, N. R. Taylor
• Glasgow medical journal
• 1955

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