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A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
TLDR
This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials. Expand
Acute and Long‐Term Outcomes of Catheter Ablation of Atrial Fibrillation Using the Second‐Generation Cryoballoon versus Open‐Irrigated Radiofrequency: A Multicenter Experience
TLDR
This study examines the acute/long‐term CAAF outcomes using these 2 strategies using the second‐generation cryoballoon (CB‐2) versus point‐by‐point radiofrequency (RF). Expand
Maintenance of patency after thrombolysis in stenotic coronary arteries requires combined inhibition of thrombin and platelets.
TLDR
The combination of hirudin and aspirin in doses that do not markedly perturb hemostasis prevents early reocclusion after thrombolysis despite the presence of severe stenosis. Expand
Relative Efficacy of Antithrombin Compared With Antiplatelet Agents in Accelerating Coronary Thrombolysis and Preventing Early Reocclusion
TLDR
Inhibition of thrombin by recombinant hirudin facilitates thrombolysis and maintains patency of coronary arteries recanalized with t-PA particularly effectively. Expand
Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots.
TLDR
Factor Xa is primarily responsible for the procoagulant activity of clots in vitro and a potential molecular mechanism for the observed efficacy of inhibitors of factor Xa in preventing recurrent thrombosis after coronary thrombolysis is suggested. Expand
Pulmonary vein reconnection following catheter ablation of atrial fibrillation using the second-generation cryoballoon versus open-irrigated radiofrequency: results of a multicenter analysis
TLDR
In this large multicenter, retrospective analysis, CAAF using the second-generation cryoballoon was associated with improved durability of PV isolation compared to open-irrigated, non-force-sensing radiofrequency and cryOBalloon ablation and PV ablation time emerged as significant predictors of durable PV isolation at repeat procedure. Expand
Long-term effectiveness of surgical treatment of ectopic atrial tachycardia.
TLDR
Results demonstrate that surgery is effective for patients with ectopic atrial tachycardias who are not easily treated with antiarrhythmic drugs, and map-guided surgery demonstrated long-term efficacy in abolishing symptoms. Expand
Nature and time course of generation of creatine kinase, MB fraction in vivo☆
TLDR
Development of assays capable of resolving all of the isoforms of MB CK that can occur in vivo might increase sensitivity for early detection of new tissue isoform release associated with acute myocardial infarction and coronary recanalization compared with currently available assays that resolve only two species. Expand
Nature and time course of generation of isoforms of creatine kinase, MB fraction in vivo.
TLDR
Development of assays capable of resolving all of the isoforms of MB CK that can occur in vivo might increase sensitivity for early detection of new tissue isoform release associated with acute myocardial infarction and coronary recanalization compared with currently available assays that resolve only two species. Expand
A Randomized , Double-Blind , Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5 AR in the Treatment of Androgenetic Alopecia
Background Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and anatomically defined within a givenExpand
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