• Publications
  • Influence
Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas
Reflexes from the carotid body have been implicated in cardiorespiratory disorders associated with chronic intermittent hypoxia (CIH). To investigate whether CIH causes functional and/or structuralExpand
  • 402
  • 40
  • PDF
Peripheral chemoreceptors: function and plasticity of the carotid body.
The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forwardExpand
  • 315
  • 31
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.
Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of other members ofExpand
  • 356
  • 23
  • PDF
Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
Chronic intermittent hypoxia (CIH) occurs in patients with sleep apnoea and has adverse effects on multiple physiological functions. Previous studies have shown that reflexes arising from carotidExpand
  • 312
  • 16
Oxygen sensing in the body.
This review is divided into three parts: (a) The primary site of oxygen sensing is the carotid body which instantaneously respond to hypoxia without involving new protein synthesis, and isExpand
  • 262
  • 15
NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.
Respiratory motoneuron response to hypoxia is reflex in nature and carotid body sensory receptor constitutes the afferent limb of this reflex. Recent studies showed that repetitive exposures toExpand
  • 156
  • 13
The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation
Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitiveExpand
  • 186
  • 11
5‐HT evokes sensory long‐term facilitation of rodent carotid body via activation of NADPH oxidase
5‐Hydroxytryptamine (5‐HT) evokes long‐term activation of neuronal activity in the nervous system. Carotid bodies, the sensory organs for detecting arterial oxygen, express 5‐HT. In the present studyExpand
  • 75
  • 11
NO and CO as second messengers in oxygen sensing in the carotid body.
  • N. Prabhakar
  • Chemistry, Medicine
  • Respiration physiology
  • 1 April 1999
It is being increasingly appreciated that nitric oxide (NO) and carbon monoxide (CO) are synthesized in mammalian cells and that they function as second messengers. The purpose of this article is toExpand
  • 214
  • 10
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
To investigate whether the transcriptional activator hypoxia-inducible factor 1 (HIF-1) is required for ventilatory responses to hypoxia, we analyzed mice that were either wild type or heterozygousExpand
  • 267
  • 10
  • PDF