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Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
BACKGROUND In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain. METHODS We randomly assigned 11,140 patients with type 2 diabetes toExpand
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Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
BACKGROUND The mechanisms by which hypertension causes vascular events are unclear. Guidelines for diagnosis and treatment focus only on underlying mean blood pressure. We aimed to reliably establishExpand
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Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian
BACKGROUND The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics and beta blockers used. For aExpand
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Effects of Once‐Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes
BACKGROUND The cardiovascular effects of adding once‐weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS We randomly assigned patients with type 2Expand
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Hypertension Treatment and Control in Five European Countries, Canada, and the United States
Abstract—Levels of hypertension treatment and control have been noted to vary between Europe and North America, although direct comparisons with similar methods have not been undertaken. In thisExpand
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Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States.
CONTEXT Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences inExpand
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Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional
Objective Comparison of recent national survey data on prevalence, awareness, treatment and control of hypertension in England, the USA and Canada, and correlation of these parameters with eachExpand
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Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IV
Summary of recommendationsProvide advice on life-style modifications for all people with high blood pressure (BP) and those with borderline or high-normal BP. Advice on effective nonpharmacologicalExpand
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Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
BACKGROUND Degludec is an ultralong‐acting, once‐daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open‐label studies have shown lowerExpand
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