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Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity
Melanocortin-4 receptor gene (MC4R) variants are associated with obesity and binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (POMC) and leptin receptor gene (LEPR)Expand
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Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees
OBJECTIVE— Melanocortin-4 receptor (MC4R) deficiency is the most frequent genetic cause of obesity. However, there is uncertainty regarding the degree of penetrance of this condition, and theExpand
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  • Open Access
Successful Multi-Intervention Treatment of Severe Obesity: A 7-year Prospective Study with 96% Follow-up
BackgroundNo long-term, high participation study of the outcome of bariatric surgery has examined how a multi-intervention approach to the treatment of severe obesity can achieve and sustain weightExpand
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  • Open Access
Management of failed adjustable gastric banding.
BACKGROUND About 100,000 adjustable gastric band placements have been performed worldwide, but more than 10% of patients have needed reoperation for insufficient weight loss or device-relatedExpand
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Bowel Habits After Bariatric Surgery
BackgroundDisordered bowel habits might influence quality of life after bariatric surgery. Different types of bariatric operations—gastric banding (AGB), Roux-en-Y gastric bypass (RYGB), orExpand
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Health-Related Quality of Life in Patients with Class II and Class III Obesity
Background: Severe obesity may substantially impact quality of life. We estimated the health-related quality of life (HRQoL) in patients with class II and class III obesity, and explored the impactExpand
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Severe Recurrent Hypoglycemia after Gastric Bypass Surgery
BackgroundBariatric surgery is, at present, the most effective method to achieve major, long-term weight loss in severely obese patients. Recently, severe recurrent symptomatic hyperinsulinemicExpand
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Impact of Age, Sex and Body Mass Index on Outcomes at Four Years after Gastric Banding
Background: Adjustable gastric banding for weight reduction in severely obese persons allows reversible individualized restriction during postoperative follow-up. It is unknown whether preoperativeExpand
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G protein polymorphisms do not predict weight loss and improvement of hypertension in severely obese patients
Both the gene encoding the α subunit of G stimulatory proteins (GNAS1) and the β3 subunit gene (GNB3) of G proteins are associated with obesity and/or hypertension. Moreover, the TT/TC825Expand
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Salvage of Gastric Restriction following Staple-Line Dehiscence after Vertical Banded Gastroplasty by Insertion of an Adjustable Gastric Band
Background: Vertical banded gastroplasty (VBG) has been a common and safe surgical treatment for morbid obesity. However, the complication of staple-line dehiscence (SLD) results in VBG failure. WeExpand
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