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The role of amino acid transporters in nutrition
  • N. Poncet, P. Taylor
  • Biology, Medicine
  • Current opinion in clinical nutrition and…
  • 1 January 2013
Purpose of reviewWe consider recent advances in epithelial amino acid transport physiology and our understanding of the functioning of amino acid transporters as sensors, as well as carriers, ofExpand
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The Catalytic Subunit of the System L1 Amino Acid Transporter (Slc7a5) Facilitates Nutrient Signalling in Mouse Skeletal Muscle
The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6KExpand
  • 47
  • 1
  • Open Access
Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos
Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that theExpand
  • 2
  • 1
  • Open Access
Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function
Amino acid absorption requires luminal uptake into and subsequent basolateral efflux out of epithelial cells, with the latter step being critical to regulate the intracellular concentration of theExpand
  • 3
Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans
Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We showExpand
  • 4
  • Open Access
Intestinal epithelial ablation of Pit‐2/Slc20a2 in mice leads to sustained elevation of vitamin D3 upon dietary restriction of phosphate
Several Na+‐dependent phosphate cotransporters, namely NaPi‐IIb/SLC34A2, Pit‐1/SLC20A1 and Pit‐2/SLC20A2, are expressed at the apical membrane of enterocytes but their contribution to activeExpand
Tissue-specific deletion of mouse basolateral uniporter LAT4 (Slc43a2) reveals its crucial role in small intestine and kidney amino acid transport.
KEY POINTS SUMMARY LAT4 is a broadly expressed uniporter selective for essential branched chain amino acids, methionine and phenylalanine that is involved in epithelial transport. Its global deletionExpand