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Developing a drug-like natural product library.
- R. Quinn, A. Carroll, +5 authors S. Muresan
- Engineering, Medicine
- Journal of natural products
- 8 February 2008
Addressing drug-like/lead-like properties of biologically active small molecules early in a lead generation program is the current paradigm within the drug discovery community. Lipinski's "rule of… Expand
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities,… Expand
Direct Screening of Natural Product Extracts Using Mass Spectrometry
The authors describe first a proof-of-concept experiment to show direct affinity screening using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) is… Expand
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.
- A. Maresca, C. Temperini, +5 authors C. Supuran
- Chemistry, Medicine
- Journal of the American Chemical Society
- 10 February 2009
The X-ray crystal structure of the adduct between the zinc metalloenzyme carbonic anhydrase II (CA, EC 126.96.36.199) with the recently discovered natural product coumarin derivative… Expand
Isolation of psammaplin A 11'-sulfate and bisaprasin 11'-sulfate from the marine sponge Aplysinella rhax.
Psammaplin A 11'-sulfate (3) and bisaprasin 11'-sulfate (4) have been isolated from the marine sponge Aplysinella rhax, along with the known psammaplin A (1). Their structures were determined on the… Expand
Production and secretion of recombinant thaumatin in tobacco hairy root cultures
Production of recombinant proteins in plant cell or organ cultures and their secretion into the plant cell culture medium simplify the purification procedure and increase protein yield. In this… Expand
Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections.
- U. R. Abdelmohsen, Srikkanth Balasubramanian, +4 authors U. Hentschel
- Biology, Medicine
- The Lancet. Infectious diseases
- 1 February 2017
Antibiotics have revolutionised medicine in many aspects, and their discovery is considered a turning point in human history. However, the most serious consequence of the use of antibiotics is the… Expand
Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry
Natural products are well known for their biological relevance, high degree of three-dimensionality, and access to areas of largely unexplored chemical space. To shape our understanding of the… Expand
Cytotoxic evaluation of alkaloids and isoflavonoids from the Australian tree Erythrina vespertilio.
- M. Iranshahi, Hoan Vu, N. Pham, D. Zencak, P. Forster, R. Quinn
- Planta medica
- 21 February 2012
A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11- β-methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth.… Expand
Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi.
Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was… Expand