• Publications
  • Influence
Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA
TLDR
A framework to identify interactions between brain functional and genetic information is constructed and the findings provide a proof‐of‐concept that genomic SNP factors can be investigated by using endophenotypic imaging findings in a multivariate format. Expand
Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets
TLDR
Gene ontology analyses revealed that HuD targets are enriched in signaling pathways involved in neuronal differentiation and that many of these mRNAs encode other RBPs, translation factors and actin-binding proteins. Expand
Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain
TLDR
This distributional pattern raises the question of whether synapses in all areas containing high levels of GAP-43/B-50 are capable of undergoing functional plasticity, or whether the protein may function in some of these areas in some other capacity. Expand
The RNA-binding protein HuD is required for GAP-43 mRNA stability, GAP-43 gene expression, and PKC-dependent neurite outgrowth in PC12 cells.
TLDR
The results suggest that HuD plays a critical role in PKC-mediated neurite outgrowth in PC12 cells and that this protein does so primarily by promoting the stabilization of the GAP-43 mRNA. Expand
Overexpression of HuD Accelerates Neurite Outgrowth and Increases GAP-43 mRNA Expression in Cortical Neurons and Retinoic Acid-Induced Embryonic Stem Cells in Vitro
TLDR
The results demonstrate that HuD functions in the initiation of neurite outgrowth in a manner due, at least in part, to its regulation of GAP-43 expression. Expand
The Elav-like Proteins Bind to a Conserved Regulatory Element in the 3′-Untranslated Region of GAP-43 mRNA*
TLDR
This study has shown that purified recombinant HuD can bind with high affinity to GAP-43 mRNA, and mapped the binding site to a highly conserved 26-nucleotide sequence within the regulatory element. Expand
Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia
TLDR
These data support cytoarchitectural observations that the cerebral cortex of schizophrenic patients has extensive pathology and indicate a complicated molecular adaptation to the causative factors of schizophrenia. Expand
Overexpression of HuD, but Not of Its Truncated Form HuD I+II, Promotes GAP‐43 Gene Expression and Neurite Outgrowth in PC12 Cells in the Absence of Nerve Growth Factor
TLDR
It is indicated that HuD is sufficient to increase GAP‐43 gene expression and neurite outgrowth in the absence of NGF and that the third RRM in the protein is critical for this function. Expand
Role of HuD and other RNA‐binding proteins in neural development and plasticity
TLDR
The function of the embryonic lethal abnormal vision (ELAV)/Hu family of nervous system‐specific RNA‐binding proteins, with a special emphasis on HuD, a member of this family that controls GAP‐43 mRNA stability and expression is discussed. Expand
The RNA‐binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity
TLDR
The present review is designed to provide a comprehensive and updated view of HuD as an RBP in the nervous system and highlights the role of Hu D in multiple aspects of a neuron's life from early differentiation to changes in mature neurons during learning paradigms and in response to injury and regeneration. Expand
...
1
2
3
4
5
...