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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
We have designed a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns. The gene encoding the yeast… Expand
Evidence that stem cells reside in the adult Drosophila midgut epithelium
Adult stem cells maintain organ systems throughout the course of life and facilitate repair after injury or disease. A fundamental property of stem and progenitor cell division is the capacity to… Expand
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.
Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We provide evidence from Drosophila that a group of membrane-associated… Expand
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
- J. Axelrod, J. Miller, J. Shulman, R. Moon, N. Perrimon
- Medicine, Biology
- Genes & development
- 15 August 1998
In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz) and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may utilize DFz2 as a… Expand
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
The generation of membrane domains with distinct protein constituents is a hallmark of cell polarization. In epithelia, segregation of membrane proteins into apical and basolateral compartments is… Expand
An endogenous small interfering RNA pathway in Drosophila
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of ∼22… Expand
The Developmental Transcriptome of Drosophila melanogaster
Drosophila melanogaster is one of the most well studied genetic model organisms, nonetheless its genome still contains unannotated coding and non-coding genes, transcripts, exons, and RNA editing… Expand
Sequential activation of signaling pathways during innate immune responses in Drosophila.
Innate immunity is essential for metazoans to fight microbial infections. Genome-wide expression profiling was used to analyze the outcome of impairing specific signaling pathways after microbial… Expand
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a… Expand
A genome-scale shRNA resource for transgenic RNAi in Drosophila
Existing transgenic RNAi resources in Drosophila melanogaster based on long double-stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in gene knockdown during… Expand