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The complete genome sequence of Escherichia coli K-12.
The 4,639,221-base pair sequence of Escherichia coli K-12 is presented and reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident. Expand
progressiveMauve: Multiple Genome Alignment with Gene Gain, Loss and Rearrangement
A new method to align two or more genomes that have undergone rearrangements due to recombination and substantial amounts of segmental gain and loss is described, demonstrating high accuracy in situations where genomes have undergone biologically feasible amounts of genome rearrangement, segmental loss and loss. Expand
Mauve: multiple alignment of conserved genomic sequence with rearrangements.
This work presents methods for identification and alignment of conserved genomic DNA in the presence of rearrangements and horizontal transfer and evaluated the quality of Mauve alignments and drawn comparison to other methods through extensive simulations of genome evolution. Expand
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
It is found that lateral gene transfer is far more extensive than previously anticipated and 1,387 new genes encoded in strain-specific clusters of diverse sizes were found in O157:H7, including candidate virulence factors, alternative metabolic capacities, several prophages and other new functions—all of which could be targets for surveillance. Expand
Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
- R. Welch, V. Burland, +16 authors F. Blattner
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 5 December 2002
The complete genome sequence of uropathogenic Escherichia coli, strain CFT073 is presented and Comparisons indicate that extraintestinal pathogenic E. coli arose independently from multiple clonal lineages. Expand
Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7
The complete 43,359-bp sequence of the locus of enterocyte effacement (LEE) from EDL933 is reported, which suggests recombinational divergence coupled with natural selection and has implications for the understanding of the interaction of both pathogens with their host, for the emergence of O157:H7, and for the evolutionary history of pathogens in general. Expand
Patterns of nucleotide composition at fourfold degenerate sites of animal mitochondrial genomes
Three statistics (%GC, GC-skew, and AT-s Skew) can be used to describe the overall patterns of nucleotide composition in DNA sequences, which reflect the substitution process in mitochondrial genomes. Expand
Escherichia coli K-12: a cooperatively developed annotation snapshot—2005
A snapshot analysis based on the most recent genome sequences of two E.coli K-12 strains allows comparison of their genotypes and mutant status of alleles. Expand
Genome Sequence of Yersinia pestis KIM
The KIM genome sequence was compared with that of Y. pestis CO92, biovar Orientalis, revealing homologous sequences but a remarkable amount of genome rearrangement for strains so closely related, in a manner consistent with present knowledge of replication and recombination. Expand
The complete DNA sequence and analysis of the large virulence plasmid of Escherichia coli O157:H7.
- V. Burland, Y. Shao, N. Perna, Guy Plunkett, H. Sofia, F. Blattner
- Biology, Medicine
- Nucleic acids research
- 1 September 1998
In the complete sequence of pO157, the large virulence plasmid of EHEC strain O157:H7 EDL 933, insights were obtained from patterns of DNA composition as well as the pathogenic and 'housekeeping' gene segments. Expand