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T cell responses: naive to memory and everything in between.
THE MAMMALIAN IMMUNE SYSTEM can be broadly divided into two main arms: innate and adaptive immunity. As its name implies, the cells and receptors of the innate immune system are critical for theExpand
Engagement of Toll‐like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction
Mycoplasma arthritidis mitogen (MAM) is a superantigen (SAg) from M. arthritidis, an agent of murine toxic shock syndrome and arthritis. We previously demonstrated that C3H/HeJ and C3H/HeSnJ miceExpand
Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes
Although regulatory T cells (Tregs) are well described, identifying autoaggressive effector T cells has proven more difficult. However, we identified CD4loCD40+ (Th40) cells as being necessary andExpand
IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization
Significance Traditional immunizations involve the controlled introduction of attenuated bacteria or viruses, allowing for generation of immunity prior to exposure to the dangerous native pathogen.Expand
T cell vaccinology: exploring the known unknowns.
The objective of modern vaccine development is the safe generation of protective long-term immune memory, both prophylactic and therapeutic. Live attenuated vaccines generate potent cellular andExpand
A unique T cell subset described as CD4loCD40+ T cells (TCD40) in human type 1 diabetes.
Human T1D pancreatic lymph nodes contain diabetes-autoantigen responsive T cells but identification of such T cells in the periphery has proven difficult. Here we describe a unique T cell subsetExpand
Mucosal Immunity in the Female Murine Mammary Gland
The mammary gland is not classically considered a mucosal organ, although it exhibits some features common to mucosal tissues. Notably, the mammary epithelium is contiguous with the externalExpand
An analytical workflow for investigating cytokine profiles
Understanding cytokine profiles of disease states has provided researchers with great insight into immunologic signaling associated with disease onset and progression, affording opportunities forExpand
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer
BackgroundWomen diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical variables known to impactExpand
Inflammatory Lipoproteins Purified from a Toxigenic and Arthritogenic Strain of Mycoplasma arthritidis Are Dependent on Toll-Like Receptor 2 and CD14
ABSTRACT Mycoplasma arthritidis is a naturally occurring murine pathogen, and the disease model has been used extensively to understand inflammatory mechanisms. Recently, Triton X-114 extracts of aExpand