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Genome-wide association study identifies 74 loci associated with educational attainment
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we… Expand
Identification of late-onset hypogonadism in middle-aged and elderly men.
BACKGROUND The association between aging-related testosterone deficiency and late-onset hypogonadism in men remains a controversial concept. We sought evidence-based criteria for identifying… Expand
Genome-wide association studies establish that human intelligence is highly heritable and polygenic
General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in intelligence are strongly associated… Expand
Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study.
- A. Tajar, G. Forti, +16 authors F. Wu
- The Journal of clinical endocrinology and…
- 19 February 2010
CONTEXT The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized. OBJECTIVE Our objective was to investigate… Expand
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3–7, but… Expand
Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
textabstractIntelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial… Expand
Prevalence and symptom profiling of oropharyngeal dysphagia in a community dwelling of an elderly population: a self-reporting questionnaire survey.
- G. Holland, V. Jayasekeran, N. Pendleton, M. Horan, M. Jones, S. Hamdy
- Diseases of the esophagus : official journal of…
- 1 April 2009
Symptomatic dysphagia is believed to be more common in the older population; however, the factors that predict age-related dysphagia are less well-understood. Here, we describe a questionnaire-based… Expand
Brain‐derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly
A functional brain‐derived neurotrophic factor (BDNF) gene polymorphism (Val66Met) that alters activity‐dependent secretion has previously been reported to influence cognitive functioning. A large… Expand
Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS).
INTRODUCTION Limited information is available concerning the general and sexual health status of European men. AIM To investigate the age-related changes in general and sexual health in middle-aged… Expand
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
- D. Lee, A. Tajar, +18 authors F. Wu
- Psychology, Medicine
- Journal of Neurology, Neurosurgery, and…
- 21 May 2009
Background: Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to… Expand