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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causes… Expand
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.
Linear ubiquitination is crucial for innate and adaptive immunity. The linear ubiquitin chain assembly complex (LUBAC), consisting of HOIL-1, HOIP, and SHARPIN, is the only known ubiquitin ligase… Expand
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling.
The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway. TNF signaling can result in different… Expand
Ubiquitin in the immune system
Ubiquitination is a post‐translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination… Expand
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors, including TNFR11. Deficiency in the LUBAC… Expand
Mitochondrial permeabilisation engages NF-κB dependent anti-tumour activity under caspase deficiency
- Evangelos Giampazolias, B. Zunino, +24 authors S. W. Tait
- Biology, Medicine
- Nature Cell Biology
- 28 August 2017
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase… Expand
Caspase-3 Protects Stressed Organs against Cell Death
- H. Khalil, N. Peltzer, +8 authors C. Widmann
- Biology, Medicine
- Molecular and Cellular Biology
- 4 September 2012
ABSTRACT The ability to generate appropriate defense responses is crucial for the survival of an organism exposed to pathogenesis-inducing insults. However, the mechanisms that allow tissues and… Expand
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene activation and to prevent cell death induced by TNF. Here, we… Expand
UV-B induces cytoplasmic survivin expression in mouse epidermis.
Cell Death and Inflammation - A Vital but Dangerous Liaison.
The immune system has developed multiple ways to fight infection. Yet, it is constantly tasked with overcoming newly developing pathogenic mechanisms of resistance to host immunity. In most mammals,… Expand