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- Publications
- Influence
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
- Tanya M. Teslovich, K. Musunuru, +206 authors S. Kathiresan
- Biology, Medicine
- Nature
- 5 August 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery… Expand
Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, +479 authors E. K. Speliotes
- Biology, Medicine
- Nature
- 12 February 2015
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass… Expand
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, E. Schmidt, +256 authors G. Abecasis
- Medicine, Biology
- Nature Genetics
- 6 October 2013
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery… Expand
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- J. Dupuis, C. Langenberg, +301 authors I. Barroso
- Biology, Medicine
- Nature Genetics
- 17 January 2010
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting… Expand
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- A. Morris, B. Voight, +201 authors M. McCarthy
- Biology, Medicine
- Nature Genetics
- 26 July 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and… Expand
Defining the role of common variation in the genomic and biological architecture of adult human height
- A. Wood, T. Esko, +442 authors T. Frayling
- Biology, Medicine
- Nature Genetics
- 8 September 2014
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different… Expand
Large-scale association analysis identifies new risk loci for coronary artery disease
- P. Deloukas, S. Kanoni, +180 authors N. Samani
- Biology, Medicine
- Nature Genetics
- 2013
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance,… Expand
Genome-wide association study identifies 74 loci associated with educational attainment
- A. Okbay, J. Beauchamp, +252 authors D. Benjamin
- Biology, Medicine
- Nature
- 31 March 2016
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we… Expand
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
- N. Wray, S. Ripke, +213 authors P. Sullivan
- Biology, Medicine
- Nature Genetics
- 17 February 2018
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based… Expand
New genetic loci link adipose and insulin biology to body fat distribution
- D. Shungin, T. Winkler, +403 authors K. Mohlke
- Biology, Medicine
- Nature
- 16 December 2014
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body… Expand