N. Pavletich

Publications180
h-index67
Citations33,897
Highly Influential Citations2,036
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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
TLDR
The crystal structure of a complex containing the core domain of human p53 and a DNA binding site provides a framework for understanding how mutations inactivate it, and supports the hypothesis that DNA binding is critical for the biological activity of p53.
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Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
TLDR
The structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF complex suggests that Cul1 may contribute to catalysis through the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supported by Cul1 mutations designed to eliminate the rigidity of the scaffold.
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Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association
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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
TLDR
The structure of the histone deacetylase catalytic core is described, as revealed by the crystal structure of a homologue from the hyperthermophilic bacterium Aquifex aeolicus, and it is established that the residues that make up the active site and contact the inhibitors are conserved across the HDAC family.
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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
TLDR
The crystal structure of the human cyclinA-cyclin-dependent kinase2-ATP complex has been determined at 2.3 A resolution and activates the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.
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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
TLDR
It is established that BRCA2 functions directly in homologous recombination and provide a structural and biochemical basis for understanding the loss of recombination-mediated DSB repair in BRCa2-associated cancers.
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Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
TLDR
The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-Residue transactivation domain peptide of p53 revealed that MDM 2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic α helix, supporting the hypothesis thatMDM2 inactivates p53 by concealing its transactivationdomain.
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Structure of a c-Cbl–UbcH7 Complex RING Domain Function in Ubiquitin-Protein Ligases
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Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex
The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A–cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 Å. p27Kip1 binds the…
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Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression
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