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Principal components analysis corrects for stratification in genome-wide association studies
- A. Price, N. Patterson, R. Plenge, M. Weinblatt, N. Shadick, D. Reich
- BiologyNature Genetics
- 23 July 2006
This work describes a method that enables explicit detection and correction of population stratification on a genome-wide scale and uses principal components analysis to explicitly model ancestry differences between cases and controls.
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