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Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures.
TLDR
The investigation of the capacity of these flavonoids to remove iron from iron-loaded hepatocytes revealed a good relationship between this iron-chelating ability and the cytoprotective effect, increasing the prospects for the development and clinical application of these potent antioxidants. Expand
Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism
TLDR
The results suggest that ICL670 has a powerful antitumoural effect and blocks cell proliferation in neoplastic cells by a pathway different from that of CP20 and may constitute a potential adjuvant drug for anticancer therapy. Expand
The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox.
TLDR
It is suggested that ICL670A has the most efficient antitumoral effect, blocks cell proliferation by a pathway different of O-trensox and may constitute a potential drug for anticancer therapy. Expand
Kinetic evaluation of free malondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Involvement of free radicals.
TLDR
The present study relates to the effect of ferric iron supplementation on lipid peroxidation of adult rat hepatocyte pure cultures, which suggested a dissociation between the two parameters of cytotoxicity considered. Expand
EPR determination of low molecular weight iron content applied to whole rat hepatocytes.
TLDR
EPR determination of LMW iron content in whole hepatocytes could give some insight about the mechanism of induction or inhibition of a oxidative stress and the applicability of this methods for evaluating the prooxidant status during an oxidative stress was shown. Expand
Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2).
TLDR
It was observed that L-ornithine stimulation of albumin production was via polyamine synthesis, and it may be postulated that ornithine alpha-ketoglutarate acts at a pretranslational level. Expand
Prolonged Maintenance of Active Cytochrome P‐450 in Adult Rat Hepatocytes Co‐Cultured with Another Liver Cell Type
TLDR
Results indicate that when placed in co‐culture, adult hepatocytes remain differentiated for several days and suggest that such a co-culture system is an appropriate model for pharmacotoxicological studies. Expand
Isozyme shift in cultured fetal human hepatocytes: a study of pyruvate kinase and phosphofructokinase.
TLDR
Hepatocytes from a 4-month old fetus were cultured for 15 days and found that fetal hepatocytes contained some R1 (precursor) form of L-type pyruvate kinase, which can be considered as a “strong” marker of cell differentiation, while phosphofructokinase is rather a ‘weak’ marker. Expand
Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: comparison of their mechanism of protection with that of
TLDR
Data indicate that, in addition to the iron-chelating activity which represents the most important property for determining the protection capacity of these iron chelators, their free radical scavenging ability also must be taken into account. Expand
Iron load increases ferritin synthesis and secretion in adult human hepatocyte cultures.
TLDR
The present data demonstrate that, in adult human primary cultures, iron load increases ferritin synthesis and secretion in a specific manner. Expand
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