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- Publications
- Influence
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
OBJECTIVE
The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blocking… Expand
Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.
- N. Volkow, L. Chang, +10 authors N. Pappas
- Psychology, Medicine
- The American journal of psychiatry
- 1 December 2001
OBJECTIVE
The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine… Expand
Decreases in dopamine receptors but not in dopamine transporters in alcoholics.
- N. Volkow, G. Wang, +6 authors K. Piscani
- Psychology, Medicine
- Alcoholism, clinical and experimental research
- 1 December 1996
It has been hypothesized that ethanol's actions on the dopamine (DA) system may participate in addiction. The purpose of this study was to evaluate the DA system in the brain of alcoholics. We… Expand
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
The drive for food is one of the most powerful of human and animal behaviors. Dopamine, a neurotransmitter involved with motivation and reward, its believed to regulate food intake in laboratory… Expand
Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.
- N. Volkow, G. Wang, +5 authors N. Pappas
- Psychology, Medicine
- The Journal of pharmacology and experimental…
- 1 October 1999
Increases in dopamine concentration in limbic brain regions have been postulated to underlie the reinforcing effects of psychostimulant drugs in laboratory animals. However, neither the qualitative… Expand
Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.
- N. Volkow, G. Wang, +6 authors N. Pappas
- Psychology, Medicine
- The American journal of psychiatry
- 1 September 1999
OBJECTIVE
This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans.
METHOD… Expand
Regional brain metabolic activation during craving elicited by recall of previous drug experiences.
Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain… Expand
Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism.
OBJECTIVE
Despite the well-documented loss of brain dopamine activity with age, little is known about its functional consequences in healthy individuals. This study investigates the relationship… Expand
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction.
OBJECTIVE
The authors have shown that decreases in dopamine D2 receptors in cocaine abusers were associated with decreased metabolism in the cingulate and prefrontal and orbitofrontal cortices. To… Expand
Exposure to appetitive food stimuli markedly activates the human brain
TLDR