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Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
OBJECTIVE The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blockingExpand
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Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.
OBJECTIVE The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamineExpand
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Decreases in dopamine receptors but not in dopamine transporters in alcoholics.
It has been hypothesized that ethanol's actions on the dopamine (DA) system may participate in addiction. The purpose of this study was to evaluate the DA system in the brain of alcoholics. WeExpand
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“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
The drive for food is one of the most powerful of human and animal behaviors. Dopamine, a neurotransmitter involved with motivation and reward, its believed to regulate food intake in laboratoryExpand
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Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.
Increases in dopamine concentration in limbic brain regions have been postulated to underlie the reinforcing effects of psychostimulant drugs in laboratory animals. However, neither the qualitativeExpand
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Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.
OBJECTIVE This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans. METHODExpand
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Regional brain metabolic activation during craving elicited by recall of previous drug experiences.
Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brainExpand
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Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism.
OBJECTIVE Despite the well-documented loss of brain dopamine activity with age, little is known about its functional consequences in healthy individuals. This study investigates the relationshipExpand
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Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction.
OBJECTIVE The authors have shown that decreases in dopamine D2 receptors in cocaine abusers were associated with decreased metabolism in the cingulate and prefrontal and orbitofrontal cortices. ToExpand
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Exposure to appetitive food stimuli markedly activates the human brain
We assess the response of the human brain to the presentation of appetitive food stimuli during food presentation using PET and FDG. Expand
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