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Upregulations of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats
&NA; The role of ion channels expressed in sensory neurons on mechanical and thermal hyperalgesia was examined in a rat model of cisplatin‐induced peripheral neuropathy. The rats were injected with 3… Expand
P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain.
- M. Shinoda, K. Kawashima, N. Ozaki, H. Asai, K. Nagamine, Y. Sugiura
- The journal of pain : official journal of the…
- 1 July 2007
UNLABELLED The present study was undertaken to determine the role of P2X3 receptor (P2X3R) on heat hyperalgesia in a newly developed rat model of trigeminal neuropathic pain. The unilateral… Expand
Mild gastritis alters voltage-sensitive sodium currents in gastric sensory neurons in rats.
BACKGROUND & AIMS Visceral hypersensitivity can be found in more than one third of patients with dyspeptic symptoms. We hypothesized that peripheral sensitization plays an important role in the… Expand
Changes in P2X3 receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats
&NA; The pathophysiological mechanisms of orofacial deep‐tissue pain is still unclear. Previously, P2X receptors (P2XR) in sensory neurons have been shown to play a role in the signal transduction of… Expand
Models of gastric hyperalgesia in the rat.
- N. Ozaki, K. Bielefeldt, J. Sengupta, G. Gebhart
- American journal of physiology. Gastrointestinal…
- 1 September 2002
Despite the prevalence of dyspepsia, nonhuman models for study of gastric hyperalgesia are limited. We thus characterized responses to gastric distension (GD) in the absence of and after two… Expand
Differential effects of mu-, delta-, and kappa-opioid receptor agonists on mechanosensitive gastric vagal afferent fibers in the rat.
Single-fiber recordings were made from the decentralized right cervical vagus nerve (hyponodosal) of the rat. A total of 56 afferent fibers that responded to gastric distension (GD) were studied: 6… Expand
Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons.
BACKGROUND & AIMS Voltage-dependent Na+ currents are important determinants of excitability. We hypothesized that gastric inflammation alters Na+ current properties in primary sensory neurons. … Expand
Mechanosensitive properties of gastric vagal afferent fibers in the rat.
Single, teased fiber recordings were made from the decentralized right cervical vagus nerve (hyponodal) of the rat. A total of 67 afferent fibers that responded to gastric distension (GD) were… Expand
Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach.
Splanchnic nerve fibers innervating the stomach were studied in anesthetized rats; 997 fibers in the T(9) or T(10) dorsal roots were identified by electrical stimulation of the splanchnic nerve.… Expand
Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.
BACKGROUND & AIMS Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in… Expand