Molecular Characterization of Mammalian Dicarbonyl/l-Xylulose Reductase and Its Localization in Kidney*
- J. Nakagawa, S. Ishikura, K. Kitamura
- Biology, ChemistryJournal of Biological Chemistry
- 17 May 2002
The results imply that P34H and diacetyl reductase are identical tol-xylulose reduct enzyme, which is involved in the uronate cycle of glucose metabolism, and the unique localization of the enzyme in kidney suggests that it has a role other than in general carbohydrate metabolism.
Analgesic Effect of the Newly Developed S(+)‐Flurbiprofen Plaster on Inflammatory Pain in a Rat Adjuvant‐Induced Arthritis Model
- M. Sugimoto, Y. Toda, H. Matsumoto
- MedicineDrug development research (Print)
- 13 January 2016
Suppression of AGE Precursor Formation Following Unilateral Ureteral Obstruction in Mouse Kidneys by Transgenic Expression of α-Dicarbonyl/L-Xylulose Reductase
- J. Asami, H. Odani, J. Nakagawa
- Chemistry, BiologyBioscience, biotechnology and biochemistry
- 23 December 2006
Collectively, DCXR may function in the removal of renal α-dicarbonyl compounds under oxidative circumstances, but it was not sufficient to suppress acute renal fibrosis during 7 d of UUO by itself.
Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition
- N. Otsuka, K. Tsuritani, Y. Yoneda
- BiologyBrain Research
- 1 September 2009
Selective 6-endo cyclization of the acyl radicals onto the nitrogen of imine and oxazoline C-N bonds.
- Mami Tojino, N. Otsuka, T. Fukuyama, H. Matsubara, I. Ryu
- ChemistryJournal of the American Chemical Society
- 26 May 2006
Acyl radicals generated by the addition of alkyl or vinyl radicals to carbon monoxide cyclized onto the C-N bonds of imines and oxazoline with perfect 6-endo selectivity, driven by a preference for…
Tin-free radical carbonylation: thiol ester synthesis using alkyl allyl sulfone precursors, phenyl benzenethiosulfonate, and CO.
- Sangmo Kim, Sunggak Kim, N. Otsuka, I. Ryu
- ChemistryAngewandte Chemie
- 26 September 2005
Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans
- I. Yataba, N. Otsuka, Y. Hoshino
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
- 6 October 2015
Compared to the FP patch, the SFPP showed superior percutaneous absorption and greater tissue penetration of SFP into the synovial tissue, which seemed to be primarily due to its formulation.
Cyclizative radical carbonylations of azaenynes by TTMSS and hexanethiol leading to alpha-silyl- and thiomethylene lactams. Insights into the E/Z stereoselectivities.
- Mami Tojino, N. Otsuka, I. Ryu
- ChemistryOrganic and biomolecular chemistry
- 18 November 2003
Free-radical mediated cyclizative carbonylations of azaenynes were carried out using TTMSS as a radical mediator to compare the efficiency and the stereochemistry with those using tributyltin hydride, and a steric effect due to the bulky (TMS)3Si group is proposed for the E-selectivity observed in the T TMSS-mediated reaction.
Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment: Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial
- I. Yataba, N. Otsuka, I. Matsushita, H. Matsumoto, Y. Hoshino
- MedicineModern Rheumatology
- 2 January 2017
The superiority of SFPP in efficacy was demonstrated and provides an additional option for knee OA therapy, and most of AEs were mild and few AEs led to treatment discontinuation.
Suppression of Renal α‐Dicarbonyl Compounds Generated following Ureteral Obstruction by Kidney‐Specific α‐Dicarbonyl/l‐Xylulose Reductase
- H. Odani, J. Asami, J. Nakagawa
- Biology, Chemistry
- 1 April 2008
Collectively, DCXR may function in the removal of renal α‐dicarbonyl compounds under oxidative circumstances, but it is not sufficient to suppress acute renal fibrosis during 7 days UUO.