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Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury
TLDR
This study shows that developmental exposure to low levels of MeHg predisposes mice to depression and induces epigenetic suppression of BDNF gene expression in the hippocampus and induces long‐lasting repressive state of the chromatin structure at the BDNF promoter region.
Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers.
TLDR
Clinical and epidemiological findings concerning the neurodevelopmental toxicity of MeHG are reviewed and much attention is focussed on the potential impact of factors, such as diet and nutrition, gender, pattern of exposure and co-exposure to other neurotoxic pollutants, which may modulate MeHg toxic effects.
Developmental exposure to methylmercury alters learning and induces depression-like behavior in male mice.
TLDR
Novel evidence is provided that the developmental exposure to MeHg can affect not only cognitive functions but also motivation-driven behaviors and learning disturbances observed in MeHG-exposed male animals suggest reference memory impairment.
Neurobehavioural and molecular changes induced by methylmercury exposure during development
TLDR
This review summarises what is currently known about the neurodevelopmental effects of MeHg and considers the strength of different experimental approaches to study the effects of environmentally relevant exposure in vivo and in vitro.
Inherited effects of low-dose exposure to methylmercury in neural stem cells.
TLDR
It is shown that nanomolar concentrations of MeHg can induce long-lasting effects in neural stem cells (NSCs) and a decrease in global DNA methylation in the exposed cells is demonstrated, indicating that epigenetic changes may be involved in the mechanisms underlying the MeHG-induced effects.
Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner
TLDR
It is found that dietary exposure of mice to 0.3 mg/kg of PFOS or PFOA throughout pregnancy results in different distribution pattern in the offspring brain and liver, and prenatal exposure to PFCs in mice is characterized by mild alterations in motor function and it appears to be sex-related.
Neurodevelopmental toxicity of methylmercury: Laboratory animal data and their contribution to human risk assessment.
TLDR
This article provides an updated overview of the main neuromorphological and neurobehavioral changes reported in non-human primates and rodents following developmental exposure to MeHg, with particular reference to the delayed onset of symptoms and the persistency of central nervous system injury/dysfunction.
Long‐lasting neurotoxic effects of exposure to methylmercury during development
TLDR
The findings have shown that low concentrations of MeHg induce long‐lasting effects in NSCs that can potentially predispose individuals to depression, which was reported earlier to occur in experimental animals exposed to MeHG during prenatal and early postnatal development.
PFOS Induces Behavioral Alterations, Including Spontaneous Hyperactivity That Is Corrected by Dexamfetamine in Zebrafish Larvae
TLDR
Developmental exposure to PFOS in zebrafish induces spontaneous hyperactivity mediated by a dopaminergic deficit, which can be partially reversed by dexamfetamine inZebrafish larvae.
Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene
TLDR
It is hypothesized that expression of the CYP2C19 enzyme prenatally may affect brain development by metabolizing endogenous compounds influencing this development, and may have a role in interindividual susceptibility for psychiatric disorders.
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