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Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study.
PURPOSE Proliferative vitreoretinopathy (PVR) is a major cause of failure of retinal detachment surgery. It is believed to be a wound-healing process in the retina. Many of the cellular functions areExpand
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Activation and suppression of fibroblast function
The fibroblast is the central player in the wound repair and scarring processes that occur in the anterior segment of the eye. Glaucoma filtration surgery is the ultimate example of the importance ofExpand
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Risk factors for proliferative vitreoretinopathy after primary vitrectomy: a prospective study
AIM To assess clinical variables and vitreous protein as risk factors for the development of postoperative proliferative vitreoretinopathy (PVR). METHODS A prospective study was conducted on 140Expand
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A prospective study of matrix metalloproteinases in proliferative vitreoretinopathy.
PURPOSE The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healingExpand
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Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro.
PURPOSE To investigate the effect of matrix metalloproteinase (MMP) inhibition on fibroblast-mediated matrix contraction and production. METHODS Free-floating fibroblast-populated type I collagenExpand
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Single exposures to antiproliferatives: long-term effects on ocular fibroblast wound-healing behavior.
PURPOSE To determine the long-term effects of single, 5-minute exposures to 5-fluorouracil (5FU) and mitomycin-C (MMC) on Tenon's capsule fibroblast migration, growth factor production, growth factorExpand
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A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.
The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and growth factors and their receptors. TheExpand
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Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts.
PURPOSE To determine whether treatment with mitomycin-c and 5-fluorouracil induces apoptotic death in cultured subconjunctival fibroblasts. METHODS Cultured human subconjunctival Tenon's capsuleExpand
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Differences in proliferative rate and collagen lattice contraction between endotenon and synovial fibroblasts.
Injured and surgically repaired tendons heal with the formation of scar tissue. Scar tissue represents 1 of the most unpredictable factors contributing to postoperative morbidity. The main cellExpand
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Matrix metalloproteinases: a role in the contraction of vitreo-retinal scar tissue.
The most common cause of failure of retinal reattachment surgery is formation of fibrocellular contractile membranes on both surfaces of the neuroretina. This intraocular fibrosis, known asExpand
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