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Kappacin, a Novel Antibacterial Peptide from Bovine Milk
TLDR
It is demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans and Porphyromonas gingivalis and against Escherichia coli.
The outer membrane protein LptO is essential for the O‐deacylation of LPS and the co‐ordinated secretion and attachment of A‐LPS and CTD proteins in Porphyromonas gingivalis
TLDR
The results suggest that LPS deacylation by LptO is linked to the co‐ordinated secretion of A‐LPS and CTD proteins by a novel secretion and attachment system to form a structured surface layer.
Divalent Metal Cations Increase the Activity of the Antimicrobial Peptide Kappacin
TLDR
Kappacin has a membranolytic, antibacterial effect that is enhanced by the presence of divalent cations.
A Novel Porphyromonas gingivalis FeoB Plays a Role in Manganese Accumulation*
TLDR
Results indicate that FeoB2 is not involved in iron transport but plays a novel role in manganese transport.
Porphyromonas gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors.
TLDR
Cryo-transmission electron microscopy analysis revealed that an electron dense surface layer known to comprise CTD proteins accounted for a large proportion of the OMVs' volume providing an explanation for the enrichment of CTDprotein, finding that P. gingivalis is able to specifically concentrate and release a large number of its virulence factors into the environment in the form of OMVs.
An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone Loss1
TLDR
The results suggest that when the RgpA-Kgp complex, or functional binding motif or active site peptides are used as a vaccine, they induce a Th2 response that blocks function of the RGPA-kgp complex and protects against periodontal bone loss.
Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines.
TLDR
The disparate effects of a givenprotein corona on particle-cell interactions are demonstrated, highlighting the correlation between protein corona conformation in situ and relevant biological characteristics for biological functionalities.
Oral health risk factors for bisphosphonate-associated jaw osteonecrosis.
TLDR
In participants with a history of bisphosphonate treatment for malignancy, periodontitis was associated with ONJ when measured using clinical parameters, serum immunoglobulin G titers against P gingivalis, and GCF interleukin-1β levels, suggesting thatperiodontitis and associated bacteria are potentially important in ONJ pathophysiology.
Macrophage Depletion Abates Porphyromonas gingivalis–Induced Alveolar Bone Resorption in Mice
TLDR
It is shown that intraoral inoculation of mice with Porphyromonas gingivalis resulted in infection, alveolar bone resorption, and a significant increase in F4/80+ macrophages inGingival and submandibular lymph node tissues.
RgpA-Kgp Peptide-Based Immunogens Provide Protection againstPorphyromonas gingivalis Challenge in a Murine Lesion Model
TLDR
It is shown that the RgpA-Kgp complex, when used as an immunogen with incomplete Freund adjuvant (IFA), protects against challenge with invasive and noninvasive strains of P. gingivalis in the murine lesion model.
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