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The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus
Summary Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure. Some of the cellular pathways mediating leptin’sExpand
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Function and Pharmacology of Spinally-Projecting Sympathetic Pre-Autonomic Neurones in the Paraventricular Nucleus of the Hypothalamus
The paraventricular nucleus (PVN) of the hypothalamus has been described as the "autonomic master controller". It co-ordinates critical physiological responses through control of theExpand
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Electric/dielectric properties of composites filled with onion-like carbon and multiwalled carbon nanotubes
The dielectric/electric properties of polyurethane composites filled with carbon nanotubes (CNTs), onion-like carbon (OLC) and mixed onion-like carbon/carbon nanotubes are compared across a wideExpand
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Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the Gnas locus is due to increased sympathetic tone
•  What is the central question of this study? Previously, we showed that Gnasxl knock‐out mice are lean and hypermetabolic, with increased sympathetic stimulation of adipose tissue. Do these miceExpand
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Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice
Abstract To study the effects of an analog of the gut-produced hormone peptide YY (PYY3-36), which has increased selectivity for the Y2 receptor; specifically, to record its effects on food intakeExpand
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PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia
Background: Glucose-sensing neurons are located in several parts of the brain, but are concentrated in the ventromedial nucleus of the hypothalamus (VMH). The importance of these VMH neurons inExpand
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TRPV4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus
Transient receptor potential vanilloid type 4 (TRPV4) and calcium‐activated potassium channels (KCa) mediate osmosensing in many tissues. Both TRPV4 and KCa channels are found in the paraventricularExpand
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Postnatal Changes in the Expression Pattern of the Imprinted Signalling Protein XLαs Underlie the Changing Phenotype of Deficient Mice
The alternatively spliced trimeric G-protein subunit XLαs, which is involved in cAMP signalling, is encoded by the Gnasxl transcript of the imprinted Gnas locus. XLαs deficient mice show neonatalExpand
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The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734
Several reports have shown that the periventricular region of the brain, including the paraventricular nucleus (PVN), is critical to sensing and responding to changes in plasma osmolality. FurtherExpand
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