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Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation.
BACKGROUND Patients with bicuspid aortic valve malformations are at an increased risk of aortic dilatation, aneurysm formation, and dissection. Vascular tissues with deficient fibrillin-1Expand
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Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3.
In the failing heart, an imbalance in matrix metalloproteinases (MMPs) and their biological regulators, the tissue inhibitors of MMPs (TIMPs), may result in cardiac dilatation from matrixExpand
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Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty.
Decorin is a small proteoglycan that binds to transforming growth factor-beta (TGF-beta) and inhibits its activity. However, its interaction with platelet-derived growth factor (PDGF), involved inExpand
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Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury.
The tetracyclines function as antibiotics by inhibiting bacterial protein synthesis, but recent work has shown that they are pluripotent drugs that affect many mammalian cell functions includingExpand
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The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure.
OBJECTIVES The role of atrial myocytes and extracellular matrix (ECM) changes in atrial chamber remodeling was studied in a canine model of heart failure (HF). BACKGROUND Cardiac remodeling is aExpand
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The cell cycle: a critical therapeutic target to prevent vascular proliferative disease.
Percutaneous coronary intervention is the preferred revascularization approach for most patients with coronary artery disease. However, this strategy is limited by renarrowing of the vessel byExpand
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Diversity of soil cellulase isoenzymes is associated with soil cellulase kinetic and thermodynamic parameters
Abstract This study was conducted to determine how land management in three ecosystems including forest, rangeland, and saline desert soils affects the activity and diversity of isoenzymes, and theExpand
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The role of perlecan in arterial injury and angiogenesis.
Perlecan is a large heparan sulfate proteoglycan (HSPG), which is a major component of the vessel wall. In relation to vascular biology, perlecan has been shown to be a potent inhibitor of smoothExpand
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Effect of Silicon Nutrition on Oxidative Stress Induced by Phytophthora melonis Infection in Cucumber.
The effect of silicon nutrition on root rot of cucumber caused by Phytophthora melonis was studied in a greenhouse experiment. Two cucumber cultivars (Cucumis sativus 'Dominus' and 'Super Dominus')Expand
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Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor.
OBJECTIVES This study compared the extracellular matrix (ECM) and cellular responses after stenting to balloon angioplasty (BA) and to determine the late effects of matrix metalloproteinase (MMP)Expand
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