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A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds.
The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of fucoidans obtained from nine species of brown algae were studied to provide a new rationale for the development of potential drugs for thrombosis, inflammation, and tumor progression.
Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
A fucoidan consisting of L-fucose, sulfate and acetate in a molar proportion of 1:1.23:0.36 was isolated from the Pacific brown seaweed Fucus evanescens. The structures of its desulfated and
A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.
A fucoidan fraction consisting of L-fucose, sulfate, and acetate in a molar proportion of 1:1.21:0.08 was isolated from the brown seaweed Fucus distichus collected from the Barents Sea. The 13C NMR
Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima.
The polysaccharide composition of a fucoidan preparation isolated from the brown alga Saccharina latissima was reinvestigated and it was shown that even a single algal species may contain, at least in minor amounts, several sulfatedpolysaccharides differing in molecular structure.
Structure of a fucoidan from the brown seaweed Fucus serratus L.
The fucoidan structure was investigated by 1D and 2D 1H and 13C NMR spectroscopy of its desulfated and de-O-acetylated derivatives as well as by methylation analysis of the native and Desulfated polysaccharides.
Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
It is reported that many microbial pathogens lacking an identifiable intercellular adhesion or polyglucosamine locus produce PNAG, including Gram-positive, Gram-negative, and fungal pathogens, as well as protozoa, e.g., Trichomonas vaginalis, Plasmodium berghei, and sporozoites and blood-stage forms of PlasModium falciparum.
Polysaccharides of algae: 60. Fucoidan from the pacific brown alga Analipus japonicus (Harv.) winne (Ectocarpales, Scytosiphonaceae)
A fucoidan containing L-fucose, sulfate, and O-acetyl groups at a molar ratio 3:2:1, as well as minor amounts of xylose, galactose, and uronic acids was isolated from the brown alga Analipus
Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed
Sulfated fucans are mainly responsible for the anti-inflammatory, anticoagulant, anti-angiogenic, and antitumor activities of sulfated polysaccharides from L. saccharina brown seaweed.
Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting on O-Glucosylated Notch Epidermal Growth Factor Repeats*
The epidermal growth factor repeats of the Notch receptor are extensively glycosylated with three different O-glycans. O-Fucosylation and elongation by the glycosyltransferase Fringe have been well
Opsonic and Protective Properties of Antibodies Raised to Conjugate Vaccines Targeting Six Staphylococcus aureus Antigens
Opsonic antibodies mediating killing of multiple S. aureus strains were elicited for all three vaccines and showed carbohydrate antigen-specific reductions in the tissue bacterial burdens in animal models of S.aureus skin abscesses, pneumonia, and nasal colonization, indicating difficulty in achieving a multi-valent vaccine targeting both the CP and PNAG antigens.