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Transcriptional landscape of repetitive elements in normal and cancer human cells
BackgroundRepetitive elements comprise at least 55% of the human genome with more recent estimates as high as two-thirds. Most of these elements are retrotransposons, DNA sequences that can insertExpand
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Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
Transposable elements (TEs) were discovered by Barbara McClintock in maize and have since been found to be ubiquitous in all living organisms. Transposition is mutagenic and organisms have evolvedExpand
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Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila
Significance Most eukaryotic genomes contain abundant transposable elements (TEs), mobile DNA elements that can replicate and move within the genome. Because of the deleterious nature of active TEs,Expand
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L1 drives IFN in senescent cells and promotes age-associated inflammation
Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution ofExpand
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Reduced Expression of MYC Increases Longevity and Enhances Healthspan
MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc(+/-)) mice exhibit increased lifespan. They show resistanceExpand
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Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but theExpand
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Long-lived Indy and calorie restriction interact to extend life span
Calorie restriction (CR) improves health and extends life span in a variety of species. Despite many downstream molecules and physiological systems having been identified as being regulated by CR,Expand
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Reorganization of chromosome architecture in replicative cellular senescence
Senescent cells acquire a unique chromosome architecture characterized by a genome-wide shrinkage of chromosome arms. Replicative cellular senescence is a fundamental biological process characterizedExpand
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Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
Background The c-Myc transcription factor is a master regulator and integrates cell proliferation, cell growth and metabolism through activating thousands of target genes. Our identification ofExpand
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Chromatin remodeling in the aging genome of Drosophila
Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging.Expand
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