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Inhibitory Effect of Efonidipine on Aldosterone Synthesis and Secretion in Human Adrenocarcinoma (H295R) Cells
Targeting aldosterone synthesis and/or release represents a potentially useful approach to the prevention of cardiovascular disease. Aldosterone production is stimulated by angiotensin II (Ang II) orExpand
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Endothelin generating pathway through endothelin1–31 in human cultured bronchial smooth muscle cells
The effects of endothelin (ET)‐11–31 and ET‐21–31, human chymase products of the corresponding big ETs, on the intracellular free Ca2+ concentration ([Ca2+]i) and [125I]‐ET‐1 binding wereExpand
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Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction.
OBJECTIVES Our aim was to investigate cardiac expression of placental growth factor (PlGF) and its clinical significance in patients with acute myocardial infarction (AMI). BACKGROUND PlacentalExpand
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Na(+)influx via Na(+)/H(+)exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes.
Protein kinase C (PKC) is one of the important signaling molecules in the development of the cardiac hypertrophic response, and activation of Na(+)/H(+)exchange is caused by PKC in myocytes. In thisExpand
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Na+Influx via Na+/H+Exchange Activates Protein Kinase C Isozymesδ and ϵ in Cultured Neonatal Rat Cardiac Myocytes
Abstract Protein kinase C (PKC) is one of the important signaling molecules in the development of the cardiac hypertrophic response, and activation of Na + /H + exchange is caused by PKC in myocytes.Expand
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Blocking T-Type Ca2+ Channels with Efonidipine Decreased Plasma Aldosterone Concentration in Healthy Volunteers
Efonidipine can block both L- and T- type Ca2+ channels. In a previous in vitro study, we clarified that efonidipine dramatically suppresses aldosterone secretion from human adrenocortical tumorExpand
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Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives.
Total synthesis of human chymase inhibitor methyllinderone has been achieved in only four steps with an overall yield of 21% from dimethyl squarate. We developed an efficient synthetic method forExpand
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Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors.
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, whichExpand
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EFFECTS OF LOSARTAN AND BENAZEPRILON ABNORMAL CIRCADIAN BLOODPRESSURE RHYTHM AND TARGETORGAN DAMAGE IN SHRSP
The effects of chronic treatment with losartan, an angiotensin II type 1 (AT1) receptor antagonist, and benazepril, an angiotensin converting enzyme (ACE) inhibitor, on target-organ damage andExpand
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Endothelin receptor subtype antagonist activity of S-0139 in various isolated rabbit and canine arteries.
Vascular responses to endothelin peptides have been proposed to be mainly mediated via subtypes of the endothelin receptor, endothelin ET(A1), endothelin ET(B1), and endothelin ET(B2). The antagonistExpand
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