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Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.
  • M. Ko, N. Naughton
  • Medicine
  • The journal of pain : official journal of the…
  • 1 May 2009
UNLABELLED Nociceptin/orphanin FQ (N/OFQ) is the endogenous peptide for the NOP receptors. Depending on the doses, intrathecal administration of N/OFQ has dual actions (ie, hyperalgesia andExpand
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The Role of Central μ Opioid Receptors in Opioid-Induced Itch in Primates
Pruritus (itch sensation) is a significant clinical problem. The aim of this study was to elucidate the roles of opioid receptor types and the site of action in opioid-induced itch in monkeys.Expand
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Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes.
BACKGROUND: The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage ofExpand
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Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes.
BACKGROUND The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage ofExpand
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Patient Selection for Day Case-eligible Surgery: Identifying Those at High Risk for Major Complications
Background:Due to economic pressures and improvements in perioperative care, outpatient surgical procedures have become commonplace. However, risk factors for outpatient surgical morbidity andExpand
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  • PDF
Orphanin FQ inhibits capsaicin‐induced thermal nociception in monkeys by activation of peripheral ORL1 receptors
Orphanin FQ (OFQ), an endogenous peptide for ORL1 receptors, has been identified. Although the actions of OFQ have much in common with those of opioid peptides at the cellular level, behavioralExpand
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An analysis of reintubations from a quality assurance database of 152,000 cases.
STUDY OBJECTIVE To determine if the majority of reintubations, a potentially preventable adverse event, were predominantly due to residual muscle relaxant effects, we analyzed our quality assuranceExpand
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Relative Analgesic Potencies of Levobupivacaine and Ropivacaine for Epidural Analgesia in Labor
Background The minimum local analgesic concentration has been defined as the median effective local analgesic concentration (EC50) in a 20-ml volume for epidural analgesia in the first stage ofExpand
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Identifying Patients at High Risk for Venous Thromboembolism Requiring Treatment After Outpatient Surgery
Objective:To identify independent predictors of 30-day venous thromboembolism (VTE) events requiring treatment after outpatient surgery. Background:An increasing proportion of surgical procedures areExpand
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An Experimental Itch Model in Monkeys: Characterization of Intrathecal Morphine-induced Scratching and Antinociception
Background: The most common side effect of spinal opioid administration is pruritus, which has been treated with a variety of agents with variable success. Currently, there are few animal modelsExpand
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