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Platelet Endothelial Aggregation Receptor 1 (PEAR1), a Novel Epidermal Growth Factor Repeat-containing Transmembrane Receptor, Participates in Platelet Contact-induced Activation*
The present study was designed to identify novel membrane proteins that signal during platelet aggregation. Because one putative mechanism for signaling by a membrane protein involvesExpand
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Distinct Transglutaminase 2-independent and Transglutaminase 2-dependent Pathways Mediate Articular Chondrocyte Hypertrophy*
Altered chondrocyte differentiation, including development of chondrocyte hypertrophy, mediates osteoarthritis and pathologic articular cartilage matrix calcification. Similar changes in endochondralExpand
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GTP Binding and Signaling by Gh/Transglutaminase II Involves Distinct Residues in a Unique GTP-binding Pocket*
Gh is a dual function protein. It has receptor signaling activity that requires GTP binding and Ca2+-activated transglutaminase (TGase) activity that is inhibited by GTP binding. Gh shows no homologyExpand
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Kinetic and mechanistic studies on the oxidation of Norfloxacin by Chloramine-B and N-Chlorobenzotriazole in acidic medium
The kinetics of oxidation of Norfloxacin [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(l-piperazinyl)-3-quinoline carboxylic acid] by chloramine-B and N-chlorobenzotriazole has been studied in aqueousExpand
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MECHANISM OF OXIDATION OF DIAZEPAM BY CHLORAMINE-B : A KINETIC APPROACH
The kinetics of the oxidation of diazepam (DZ) by Chloramine-B (CAB) has been studied in aqueous hydrochloric acid medium. The oxidation reaction follows the rate law: The dependence of theExpand
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Mechanism of oxidation of diazepam by 1-chlorobenzotriazole in acidic medium. A kinetic approach
The kinetics of oxidation of diazepam (DZ) by 1-chlorobenzotriazole (CBT) has been studied in HClO4 medium in the temperature range of 293–323 K. The reactions followed a first order dependence onExpand
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Antithrombotic Activity of PRT54021, a Potent Oral Direct Factor Xa Inhibitor, Can Be Monitored Using a Novel Prothrombinase Inhibition Bioassay.
Coagulation factor Xa (fXa) is a validated target for antithrombotic therapy and there are several on-going clinical trials testing direct fXa inhibitors. Current measures for monitoring coagulationExpand
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Abstract C196: Identification of first-in-class, highly potent FGFR kinase inhibitors that spare FGFR1
Background: The fibroblast growth factor receptor (FGFR1-4) family of tyrosine kinases plays an important role in normal physiologic processes, including angiogenesis, wound healing and regulation ofExpand
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Kinetics of Oxidation of Diazepam by N Bromosuccinimide in Acid Medium: A Mechanistic Study
The oxidation of diazepam (DZ) by N-Bromosuccinimide (NBS) in aqueous acid medium follows a first -order kinetics in [NBS] and a fractional -order each on [HCl]and [DZ]. The reaction stoichiometryExpand
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Abstract B192: Identification and characterization of highly potent and selective RET kinase inhibitors for the treatment of RET-driven cancers
Background: Activating mutations and oncogenic fusions of the RET receptor tyrosine kinase have been identified in multiple tumor types, including thyroid, lung, breast and colon carcinoma.Expand
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