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Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice.
- N. Nakashima, I. Kimura, M. Kimura, H. Matsuura
- Biology, Medicine
- Journal of natural products
- 1 March 1993
A hot-H2O extract of rhizomes of Anemarrhena asphodeloides, the Japanese sino-medicine "chimo," lowered the blood glucose level in alloxan-diabetic mice. Hypoglycemic activity-guided fractionation… Expand
Total and pancreatic amylase measured with 2-chloro-4-nitrophenyl-4-O-beta-D-galactopyranosylmaltoside.
- Y. Morishita, Y. Iinuma, N. Nakashima, K. Majima, K. Mizuguchi, Y. Kawamura
- Medicine, Chemistry
- Clinical chemistry
- 1 July 2000
BACKGROUND : Many different methods have been used to assay amylase activity, using nitrophenylated oligosaccharides as substrate; however, the hydrolysis steps in these methods are complex. … Expand
The antihyperglycaemic blend effect of traditional Chinese medicine Byakko‐ka‐ninjin‐to on alloxan and diabetic KK‐CAy mice
- I. Kimura, N. Nakashima, Y. Sugihara, C. Fu-jun, M. Kimura
- Biology, Medicine
- Phytotherapy research : PTR
- 1 September 1999
The antihyperglycaemic interaction (blend effect) of component crude drugs included in a traditional Chinese prescription, Byakko‐ka‐ninjin‐to (BN; consisted of five crude drugs, ginseng,… Expand
Effects of a New Oral Hypoglycaemic Agent (CS‐045) on Metabolic Abnormalities and Insulin Resistance in Type 2 Diabetes
- K. Mimura, F. Umeda, +7 authors H. Nawata
- Diabetic medicine : a journal of the British…
- 9 August 1994
The effects of a thiazolidinedione antidiabetic agent (CS‐045) on diabetic metabolic abnormalities were studied in a double‐blind clinical trial. Fourteen patients with Type 2 diabetes were selected… Expand
AT1 Receptor Blockade Reduces Cardiac Calcineurin Activity in Hypertensive Rats
The possible role of calcineurin in the attenuation of cardiac hypertrophy and fibrosis by blockade of the angiotensin II type 1 (AT1) receptor was investigated in Dahl salt-sensitive (DS) rats. The… Expand
[Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice].
- F. Chen, N. Nakashima, I. Kimura, M. Kimura
- Chemistry, Medicine
- Yakugaku zasshi : Journal of the Pharmaceutical…
- 1 June 1995
Averaged blood glucose levels were 400 mg/dl in nonfasted mice, and 250 mg/dl in fasted mice in 4 weeks after injection with streptozotocin (STZ, 150 mg/kg, i.v.). These mice were used for… Expand
Potentiating effects on pilocarpine-induced saliva secretion, by extracts and N-containing sugars derived from mulberry leaves, in streptozocin-diabetic mice.
- F. Chen, N. Nakashima, I. Kimura, M. Kimura, N. Asano, S. Koya
- Biology, Medicine
- Biological & pharmaceutical bulletin
- 15 December 1995
The effects of hot water extracts and six compounds of N-containing sugars, 1-deoxynojirimycin (DNJ), N-methyl-DNJ (N-Me-DNJ), 2-O-alpha-D-galactopyranosyl-DNJ (GAL-DNJ), fagomine,… Expand
Improved specificity of a new homogeneous assay for LDL-cholesterol in serum with abnormal lipoproteins.
BACKGROUND Although a homogeneous assay for serum LDL-cholesterol (LDL-C) has become a routine clinical procedure, problems remain in assay performance characteristics. METHODS We examined the… Expand
Sodium bicarbonate infusion test: a new method for evaluating parathyroid function.
We have developed a new test for estimating the secretory capacity of parathyroid hormone (PTH) from the parathyroid gland. Sodium bicarbonate solution [8.4% (w/v); 35 ml/m(2) body surface area] was… Expand
Harmful effects of inotropic agents on myocardial protection.
- H. Komai, F. Yamamoto, +7 authors Yoshiyuki Kawashima
- The Annals of thoracic surgery
- 1 October 1991
Using an isolated working rat heart model, the pretreatment effects of positive inotropic agents on ischemia-reperfusion injury were investigated. The experiment consisted of (1) working control… Expand