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Miscibility of nifedipine and hydrophilic polymers as measured by (1)H-NMR spin-lattice relaxation.
TLDR
Results indicate that (1)H-NMR spin-lattice relaxation measurements are useful for assessing the miscibility of a drug and an excipient in solid dispersions. Expand
Effect of fatty acids and monoglycerides on permeability of lipid bilayer.
TLDR
The results indicated that the increase in the membrane permeability caused by fatty acids and monoglycerides associated with the disorder in the membranes' interior and the interaction of the incorporated lipid with the polar head group of phospholipid. Expand
A Strategy for Co-former Selection to Design Stable Co-amorphous Formations Based on Physicochemical Properties of Non-steroidal Inflammatory Drugs
TLDR
The results showed a relationship between stable co-amorphous formation and the physicochemical features of the components, which should inform efficient co-former selection to design stable co -amorphous formations. Expand
Further studies on the mechanism of the absorption of ion pair complex from the rat small intestine.
TLDR
It is suggested that the mucosal surface of the small intestine plays an important role in the absorptive process of an ion pair complex. Expand
The Effects of Fatty Acids and Their Derivatives on the Intestinal Absorption of insulin in Rat
AbstractInsulin solution (25 U/ml/kg, pH 8.0) was administered with 50 mM of various C8-Cl8 fatty acid and derivative absorption enhancers to the duodenum, colon and rectum of fasted normal ratsExpand
Transport Characteristics of Ceftibuten (7432-S), a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Proton-Coupled and Stereoselective Transport of Ceftibuten
TLDR
The transport characteristics of ceftibuten in rat intestinal brush-border membrane vesicles were investigated by a rapid filtration technique and suggested H+-coupled uphill transport of cefaclor, and the uptake process appears to be stereoselective. Expand
Transport Characteristics of Ceftibuten, a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Relationship to Oligopeptide and Amino β-Lactam Transport
TLDR
Two different carrier-mediated transport systems, H+ gradient dependent and independent, may exist for oral cephems for ceftibuten and other oral antibiotics, respectively. Expand
Renin Inhibitor: Transport Mechanism in Rat Small Intestinal Brush-Border Membrane Vesicles
TLDR
The morpholino group at the N-terminal was found to be important for the uptake of CH3-18, and was competitively inhibited by tripeptides and tetrapeptides, but not by amino acids or dipeptide. Expand
Characteristics of Ceftibuten Uptake into Caco-2 Cells
TLDR
The observations suggest that ceftibuten is taken up by a carrier-mediated transport system(s) for dipeptides, especially H+-gradient-dependent, as well as various antibiotics differed in their ability to inhibit uptake, with cyclacillin showing maximum inhibition. Expand
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