Share This Author
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
KLF5 seems to be a key element linking external stress and cardiovascular remodeling, and that in vivo administration of RAR ligands affected stress responses in the cardiovascular system in a KLF5-dependent manner.
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
The findings in human cells and in mice demonstrate that RAMP2 is a key determinant of the effects of AM on the vasculature and is essential for angiogenesis and vascular integrity.
Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities.
- S. Horita, Hideomi Yamada, T. Fujita
- Biology, MedicineJournal of the American Society of Nephrology…
- 1 August 2005
Electrophysiologic analysis showed that WT, R298S, and R881C all function with 2HCO3- to 1Na+ stoichiometry and have similar extracellularNa+ affinity, indicating that reduction in Na+ affinity cannot explain the inactivation of R298s and R 881C.
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.
- T. Shindo, H. Kurihara, K. Matsushima
- Biology, MedicineThe Journal of clinical investigation
- 15 May 2000
ADAMTS-1 thus appears necessary for normal growth, fertility, and organ morphology and function, and the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease.
Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1
It appears that mild, chronic overproduction of ET-1 does not primarily cause hypertension but triggers damaging changes in the kidney which lead to the susceptibility to salt-induced hypertension.
Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
Adrenomedullin is indispensable for the vascular morphogenesis during embryonic development and for postnatal regulation of blood pressure by stimulating nitric oxide production and surviving AM+/− mice survived to adulthood.
Adrenomedullin Induces Endothelium-Dependent Vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway in Rat Aorta
Results suggested that AM induced Akt activation in the endothelium via the Ca2+/calmodulin-dependent pathway and that this was implicated in the production of NO, which in turn induced endothelia-dependent vasodilation in rat aorta.
Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis
Results indicate that G486R, like T485S, is a partial loss of function mutation without major trafficking abnormalities, while L522P causes the clinical phenotypes mainly through its inability to reach the plasma membranes.
Angiogenic Effects of Adrenomedullin in Ischemia and Tumor Growth
Results show that AM possesses novel angiogenic properties mediated by its ability to enhance VEGF expression and Akt activity, which may make AM a useful therapeutic tool for relieving ischemia; conversely, inhibitors of AM could be useful for clinical management of tumor growth.
α1a‐Adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy
The results showed that the two α1a‐adrenoceptors generated by genetic polymorphism have similar pharmacological characteristics, and the receptor‐mediated [Ca2+]i response can be desensitized in a similar manner.