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An experimental evaluation of the reputed influence of thyroxine on the cardiovascular effects of catecholamines.
Adrenergic Receptors Within the Cardiovascular System
- N. Moran
- 1 November 1963
THE CONCEPT that drugs react with specific receptors in living tissues to produce pharmacologic effects is believed to have originated with Langley in 19051 although Ehrlich and others had certainly… Expand
Age attribution in domestic sheep by skeletal and dental maturation: A pilot study of available sources
The aim of the study was to assess the quality of the available evidence pertaining to the effects of sex and castration on the timing of skeletal and dental maturation in sheep. The initial premise… Expand
Evidence for Lack of Innervation of /?‐2 Adrenoceptors in the Blood Vessels of the Gracilis Muscle of the Dog
Cardiac β-l adrenoceptors respond to sympathetic nerve stimulation (SNS), but it is not clear that SNS evokes β-2 adrenoceptor-mediated vasodilation. Sensitivity of β adrenoceptors to catecholamines… Expand
RELATION BETWEEN PHARMACOLOGIC AUGMENTATION OF CARDIAC CONTRACTILE FORCE AND THE ACTIVATION OF MYOCARDIAL GLYCOGEN PHOSPHORYLASE
The relationship between contractile force of the right ventricle and myocardial glycogen phosphorylase was investigated in the dog heart in situ. The positive inotropic effect of epinephrine,… Expand
An evaluation of the inability of cocaine to potentiate the responses to cardiac sympathetic nerve stimulation in the dog.
- R. L. Koerker, N. Moran
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 September 1971
The circulatory responses of the dog to a wide range of frequencies of cardiac sympathetic nerve stimulation and to a wide range of doses of norepinephrine, epinephrine and isoproterenol were… Expand
Contraction Dependency of the Positive Inotropic Action of Cardiac Glycosides
- N. Moran
- Biology, Medicine
- Circulation research
- 1 November 1967
The concept that the positive inotropic effect of cardiac glycosides is dependent on the contractile state of the myocardium was tested. Isolated left atria of rabbits, when driven electrically at… Expand
Pharmacological basis for the use of adrenergic agonists and antagonists in cardiogenic shock and hypotension.
Summary In the therapy of cardiogenic shock, it is difficult to develop a rationale for the use of norepinephrine and metaraminol in doses where alpha adrenergic activity predominates and which… Expand
Effects of increased reflex sympathetic activity on contractile force of the heart.
Reflexly induced changes in cardiac contractile force and arterial pressure in vagotomized dogs were compared with those produced by direct postganglionic cardiac sympathetic nerve stimulation, by ...
Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol.
DCI, a dichloro analogue of isoproterenol (β - hydroxy - N - isopropyl - 3,4 - dichloro - phenethylamine hydrochloride; Lilly 20522), selectively blocks the cardiac positive inotropic and… Expand