Skip to search formSkip to main contentSkip to account menu
  • Publications
  • Influence
An experimental evaluation of the reputed influence of thyroxine on the cardiovascular effects of catecholamines.
View on PubMed
Adrenergic Receptors Within the Cardiovascular System
  • N. Moran
  • Biology
    Circulation
  • 1 November 1963
TLDR
The definitions which follow are intended to be operational and heuristic: operational in the sense of providing a conceptual framework on which both the experimentalist and the physician can establish a common basis for understanding and classifying sympathomimetic drugs; heuristic in that this framework may provide a basis for further investigation into mechanisms of action of drugs and to the design of more nearly "perfect" drugs.
View on Wolters Kluwer
Evidence for Lack of Innervation of /?‐2 Adrenoceptors in the Blood Vessels of the Gracilis Muscle of the Dog
TLDR
Cardiac β-l adrenoceptors respond to sympathetic nerve stimulation (SNS), but it is not clear that SNS evokes β-2 adrenoceptor-mediated vasodilation, which may function as hormone receptors sensitive primarily to E released from the adrenal medulla, rather than to NE released from adrenergic nerves.
View on Wolters Kluwer
RELATION BETWEEN PHARMACOLOGIC AUGMENTATION OF CARDIAC CONTRACTILE FORCE AND THE ACTIVATION OF MYOCARDIAL GLYCOGEN PHOSPHORYLASE
TLDR
It is not possible to decide which is the primary event in catecholamine action on the heart, the effect on phosphorylase or on the contractile mechanism, or whether both are concomitant phenomena with no immediate causal relationships.
An evaluation of the inability of cocaine to potentiate the responses to cardiac sympathetic nerve stimulation in the dog.
TLDR
Even when coronary sinus outflow of norepinephrine was increased, responses to nerve stimulation were never potentiated although the positive chronotropic responses to right nerve stimulation was prolonged, and several explanations can be offered.
View on PubMed
Pharmacological basis for the use of adrenergic agonists and antagonists in cardiogenic shock and hypotension.
View on PubMed
Contraction Dependency of the Positive Inotropic Action of Cardiac Glycosides
  • N. Moran
  • Medicine, Biology
    Circulation research
  • 1 November 1967
TLDR
It is concluded that a major part of the positive inotropic effect of cardiac glycosides is contraction dependent, in contrast to the rapid development of toxic effects in atria exposed to this dose of auabain during repetitive contractions.
View on Wolters Kluwer
Effects of increased reflex sympathetic activity on contractile force of the heart.
  • M. Cotten, N. Moran
  • Biology, Medicine
    The American journal of physiology
  • 30 November 1957
Reflexly induced changes in cardiac contractile force and arterial pressure in vagotomized dogs were compared with those produced by direct postganglionic cardiac sympathetic nerve stimulation, by ...
View on PubMed
Histamine release by compound 48/80: Evidence for the depletion and repletion of calcium using chlortetracycline and45calcium
TLDR
The data provide direct evidence for the depletion of cellular Ca which is utilized by compound 48/80 to induce histamine release.
View on Springer
Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol.
TLDR
The adrenergic receptors of mammalian hearts are functionally homologous to the adrenergic inhibitory receptors of other tissues, agreeing with the hypothesis of Ahlquist that the cardiac inotropic and chronotropic sympathetic receptors are of the beta type, receptors which subserve inhibitory functions in other organs.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License