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In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum.
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened in vitro for activity against Trypanosoma brucei rhodesiense, TryPanosoma cruzi, Leishmania donovani, and Plasmodium falciparum, finding notable results against all four protozoal parasites.
Antioxidant and acetylcholinesterase inhibitory activity of selected southern African medicinal plants
The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea.
Medicinal plants with cholinesterase inhibitory activity: A Review
The present work constitutes a review of the literature on 123 species of medicinal plants that have been tested for AChE inhibitory activity and 42 plant species which have been testing for BChE inhibitedory activity to aid researchers in their study of natural products which may be useful in the treatment of AD.
Identification of compounds from the plant species Alepidea amatymbica active against HIV
Cytotoxic, antimicrobial, antioxidant, antilipoxygenase activities and phenolic composition of Ozoroa and Searsia species (Anacardiaceae) used in South African traditional medicine for treating…
Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II.
HPLC-based activity profiling was used to identify the active constituents in the extracts, and the germacranolide sesquiterpene lactones schkuhrin I and II from S. pinnata, and cynaropicrin from V. mespilifolia were identified, with IC50 values of 0.9, 1.5, and 0.23 µM, respectively.
The chemical investigation of the Amaryllidaceae and Hyacinthaceae.
- N. Moodley
Investigations into the chemistry of members of the Amaryllidaceae and Hyacinthaceae families yielded two new alkaloids, a new ceramide type compound and a known flavanoid, and a novel bufadienolide glycoside.
Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)
Eucosterol-type nortriterpenoids from Merwilla natalensis.
The bulbs of Merwilla natalensis have yielded the known spirocyclic homoisoflavanone, scillascillin, four known nortriterpenoids, and the new nortriterPenoid, which was determined by spectroscopic methods.