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Nitric oxide regulates endocytosis by S-nitrosylation of dynamin
TLDR
A general NO-dependent mechanism by which the trafficking of receptors may be regulated is suggested and the idea that pathogenic microbes and viruses may induce S-nitrosylation of dynamin to facilitate cellular entry is raised.
Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells.
TLDR
The possible utility of LPA(1) as a drug target to interfere with progression of prostate cancer is suggested, as it transduces Galphai-dependent signals to promote nuclear localization of androgen receptor and cell proliferation.
Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon
TLDR
The findings indicate that GLP-1 and blood glucose levels were unaffected by omega-3 fatty acid supplementation, however, animals that were fed fish or flaxseed oil-supplemented diets had significantly heightened colonic FFAR4 and actin expression, and reduced expression of the pro-inflammatory cytokine TNF-α compared to animals fed control diets.
Ligand-Directed Functional Heterogeneity of Histamine H1 Receptors: Novel Dual-Function Ligands Selectively Activate and Block H1-Mediated Phospholipase C and Adenylyl Cyclase Signaling
TLDR
Results suggest the trans-PAT and cis-PAB probes will be useful to study molecular mechanisms of ligand-directed GPCR multifunctional signaling and provide a mechanistic basis for exploiting H1 receptor activation for drug design purposes.
A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.
TLDR
It is concluded that (-)-trans-H(2)-PAT is an antagonist at H(1) receptors coupled to PLC/IP formation and smooth muscle contraction and there may be post-translational H( 1) receptor heterogeneity.
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