N. Moniri

Publications47
h-index14
Citations791
Highly Influential Citations32
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Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor.
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Nitric oxide regulates endocytosis by S-nitrosylation of dynamin
TLDR
A general NO-dependent mechanism by which the trafficking of receptors may be regulated is suggested and the idea that pathogenic microbes and viruses may induce S-nitrosylation of dynamin to facilitate cellular entry is raised.
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Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells.
TLDR
The possible utility of LPA(1) as a drug target to interfere with progression of prostate cancer is suggested, as it transduces Galphai-dependent signals to promote nuclear localization of androgen receptor and cell proliferation.
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Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders.
  • N. Moniri
  • Biology, Medicine
    Biochemical pharmacology
  • 15 June 2016
View on PubMed
Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon
TLDR
The findings indicate that GLP-1 and blood glucose levels were unaffected by omega-3 fatty acid supplementation, however, animals that were fed fish or flaxseed oil-supplemented diets had significantly heightened colonic FFAR4 and actin expression, and reduced expression of the pro-inflammatory cytokine TNF-α compared to animals fed control diets.
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Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail.
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Ligand-Directed Functional Heterogeneity of Histamine H1 Receptors: Novel Dual-Function Ligands Selectively Activate and Block H1-Mediated Phospholipase C and Adenylyl Cyclase Signaling
TLDR
Results suggest the trans-PAT and cis-PAB probes will be useful to study molecular mechanisms of ligand-directed GPCR multifunctional signaling and provide a mechanistic basis for exploiting H1 receptor activation for drug design purposes.
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A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.
TLDR
It is concluded that (-)-trans-H(2)-PAT is an antagonist at H(1) receptors coupled to PLC/IP formation and smooth muscle contraction and there may be post-translational H( 1) receptor heterogeneity.
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Agonist-stimulated reactive oxygen species formation regulates beta2-adrenergic receptor signal transduction.
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The role of free‐fatty acid receptor‐4 (FFA4) in human cancers and cancer cell lines
View on Wolters Kluwer
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