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Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases
Members of the AAA+ protein superfamily contribute to many diverse aspects of protein homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic machines in bacteria, AAA+Expand
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Localization of general and regulatory proteolysis in Bacillus subtilis cells
Protein degradation mediated by ATP‐dependent proteases, such as Hsp100/Clp and related AAA+ proteins, plays an important role in cellular protein homeostasis, protein quality control and theExpand
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Mechanism of fibre assembly through the chaperone–usher pathway
The chaperone–usher pathway directs the formation of adhesive surface fibres in numerous pathogenic Gram‐negative bacteria. The fibres or pili consist exclusively of protein subunits that, beforeExpand
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The role of thiol oxidative stress response in heat‐induced protein aggregate formation during thermotolerance in Bacillus subtilis
Using Bacillus subtilis as a model organism, we investigated thermotolerance development by analysing cell survival and in vivo protein aggregate formation in severely heat‐shocked cells primed by aExpand
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Chaperone-protease systems in regulation and protein quality control in Bacillus subtilis.
The Gram-positive model organism Bacillus subtilis is extremely well adapted to changing environmental conditions. The chaperone-protease ClpCP and other AAA+ proteases constitute an importantExpand
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General and regulatory proteolysis in Bacillus subtilis.
The soil-dwelling bacterium Bacillus subtilis is widely used as a model organism to study the Gram-positive branch of Bacteria. A variety of different developmental pathways, such as endosporeExpand
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Role of Hsp100/Clp Protease Complexes in Controlling the Regulation of Motility in Bacillus subtilis
The Hsp100/Clp protease complexes of Bacillus subtilis ClpXP and ClpCP are involved in the control of many interconnected developmental and stress response regulatory networks, including competence,Expand
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  • Open Access
Structural changes of TasA in biofilm formation of
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The key to unlock the Hsp100/Clp protein degradation machines of Mycobacterium
Hsp100/Clp protease complexes are molecular machines important for cellular protein homeostasis and are concurrently embedded in the control of various signal transduction networks by regulatoryExpand