Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events
- S. Uchida, Kumiko Hara, Yoshifumi Watanabe
- Biology, PsychologyNeuron
- 27 January 2011
Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2.
- Y. Yamakoshi, N. Umezawa, T. Nagano
- Chemistry, BiologyJournal of the American Chemical Society
- 24 September 2003
The results indicate that the active oxygen species primarily responsible for photoinduced DNA cleavage by C(60) under physiological conditions are reduced species such as O(2)(-)* and *OH.
Loss of Deacetylation Activity of Hdac6 Affects Emotional Behavior in Mice
- M. Fukada, A. Hanai, Y. Kawaguchi
- BiologyPLoS ONE
- 6 February 2012
The findings suggest that HDAC6-mediated reversible acetylation might contribute to maintain proper neuronal activity in serotonergic neurons, and also provide a new therapeutic target for depression.
Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.
- Takayoshi Suzuki, Sou-ichi Igari, N. Miyata
- BiologyJournal of Medicinal Chemistry
- 13 November 2008
These results provide a basis for constructing new tools for probing the biology of GPR120 and for developing new candidate therapeutic agents.
Solubilization of fullerenes into water with polyvinylpyrrolidone applicable to biological tests
- Y. Yamakoshi, T. Yagami, K. Fukuhara, S. Sueyoshi, N. Miyata
- Chemistry
- 1994
C60 and C70 can be solubilized into water with poly(vinylpyrrolidone)(PVP) and the aqueous solutions of C60 and C70 are applied to haemolysis test.
Identification of cell-active lysine specific demethylase 1-selective inhibitors.
- Rie Ueda, Takayoshi Suzuki, N. Miyata
- Biology, ChemistryJournal of the American Chemical Society
- 16 November 2009
The first small-molecule LSD1-selective inhibitors are identified and show in vivo H3K4-methylating activity and antiproliferative activity and should be useful as lead structures for anticancer drugs and as tools for studying the biological roles of LSD1.
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
- Takayoshi Suzuki, M. N. A. Khan, N. Miyata
- Chemistry, BiologyJournal of Medicinal Chemistry
- 12 June 2012
3'-phenethyloxy-2-anilinobenzamide derivatives represent an entry into a new class of SIRT2-selective inhibitors, and induced a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells, indicating selective inhibition of Sirtuin 2 in the cells.
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.
- Takayoshi Suzuki, Akiyasu Kouketsu, N. Miyata
- Biology, ChemistryJournal of Medicinal Chemistry
- 18 July 2006
Thiolate analogues designed based on the structure of an HDAC6-selective substrate and evaluated the histone/alpha-tubulin acetylation selectivity by Western blot analysis found novel histone deacetylase 6 (HDAC6)-selective inhibitors.
Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo
- T. Tsuchiya, Ikuko Oguri, Y. Yamakoshi, N. Miyata
- Biology, ChemistryFEBS Letters
- 9 September 1996
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
- Shohei Hamada, Takayoshi Suzuki, N. Miyata
- Chemistry, BiologyJournal of Medicinal Chemistry
- 14 July 2010
Findings suggest that combination treatment with JMJD2 inhibitors and LSD1 inhibitors may represent a novel strategy for anticancer chemotherapy.
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